Highlights Of Skin Disease Education FoundationÕs 42nd .

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-157.12. Katz HI, Hien NT, Prawer SE, Scott JC, Grivna EM. Betamethasone dipropionate inoptimized vehicle. Intermittent pulse dosing for extended maintenance treatment ofpsoriasis. Arch Dermatol. 1987;123:1308-1311.

Anti–IL-17 Agents in Moderate to Severe PsoriasisMedications targeting interleukin (IL)-17 are among the mostefficacious options available for treating patients with moderate tosevere psoriasis. Secukinumab and ixekizumab each has demonstrated efficacy (Psoriasis Area and Severity Index [PASI] 75, 90,and 100) superior to that of etanercept and ustekinumab.1-5Secukinumab Roughly two-thirds to 82% of patients reachedPASI 75 after 12 weeks of therapy with secukinumab 150 mg or 300mg.1 Nearly 80% of patients receiving the 300-mg dose reached PASI90 after 16 weeks of therapy (57.6% with ustekinumab; P 0.0001).Half of the patients receiving secukinumab 300 mg reached PASI75 at week 4, illustrating the early onset of action.2Efficacy and tolerability continued at 5 years, with PASI 75, 90,and 100 response rates of 88.5%, 66.4%, and 41.0%, respectively(with secukinumab 300 mg, the recommended dose for mostpatients with psoriasis).6,7 The annual adverse event (AE) incidencerate decreased from 204.6 to 87.2 per 100 subject-years from year 1to 5; no statistical comparison was performed. One death occu

The Guest Editors acknowledge the editorial assistance of Global Academy for Medical Education and Eileen A. McCaffrey, MA, medical writer, in the development of this supplement. The manuscript was reviewed and

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