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Mark Scheme (Results)Summer 2018Pearson Edexcel GCSEIn Biology (1BI0) Paper 1HPaper 1

Edexcel and BTEC QualificationsEdexcel and BTEC qualifications are awarded by Pearson, the UK’s largest awardingbody. We provide a wide range of qualifications including academic, vocational,occupational and specific programmes for employers. For further information visitour qualifications websites at www.edexcel.com or www.btec.co.uk. Alternatively,you can get in touch with us using the details on our contact us page atwww.edexcel.com/contactus.Pearson: helping people progress, everywherePearson aspires to be the world’s leading learning company. Our aim is to helpeveryone progress in their lives through education. We believe in every kind oflearning, for all kinds of people, wherever they are in the world. We’ve beeninvolved in education for over 150 years, and by working across 70 countries, in100 languages, we have built an international reputation for our commitment tohigh standards and raising achievement through innovation in education. Find outmore about how we can help you and your students at: www.pearson.com/ukSummer 2018Publications Code 1BI0 1H 1806 MSAll the material in this publication is copyright Pearson Education Ltd 2018

General Marking Guidance All candidates must receive the same treatment. Examiners must mark thefirst candidate in exactly the same way as they mark the last. Mark schemes should be applied positively. Candidates must be rewardedfor what they have shown they can do rather than penalised for omissions. Examiners should mark according to the mark scheme not according totheir perception of where the grade boundaries may lie. There is no ceiling on achievement. All marks on the mark scheme shouldbe used appropriately. All the marks on the mark scheme are designed to be awarded. Examinersshould always award full marks if deserved, i.e. if the answer matches themark scheme. Examiners should also be prepared to award zero marks ifthe candidate’s response is not worthy of credit according to the markscheme. Where some judgement is required, mark schemes will provide theprinciples by which marks will be awarded and exemplification may belimited. When examiners are in doubt regarding the application of the mark schemeto a candidate’s response, the team leader must be consulted. Crossed out work should be marked UNLESS the candidate has replaced itwith an alternative response.

Mark schemes have been developed so that the rubrics of each mark schemereflects the characteristics of the skills within the AO being targeted and therequirements of the command word. So for example the command word ‘Explain’requires an identification of a point and then reasoning/justification of the point.Explain questions can be asked across all AOs. The distinction comes whether theidentification is via a judgment made to reach a conclusion, or, making a pointthrough application of knowledge to reason/justify the point made throughapplication of understanding. It is the combination and linkage of the markingpoints that is needed to gain full marks.When marking questions with a ‘describe’ or ‘explain’ command word, the detailedmarking guidance below should be consulted to ensure consistency of marking.AssessmentObjectiveStrandElementCommand WordDescribeExplainAO1*An answer that combines the markingpoints to provide a logical descriptionAn explanation that links identification of apoint with reasoning/justification(s) asrequiredAO2An answer that combines the markingpoints to provide a logical description,showing application of knowledge andunderstandingAn explanation that links identification of apoint (by applying knowledge) withreasoning/justification (application ofunderstanding)AO31a and1bAO32a and2bAO33aAO33bAn answer that combines points ofinterpretation/evaluation to provide alogical descriptionAn explanation that combines identificationvia a judgment to reach a conclusion viajustification/reasoningAn answer that combines the markingpoints to provide a logical description of theplan/method/experimentAn explanation that combines identifying animprovement of the experimentalprocedure with a linkedjustification/reasoning*there will be situations where an AO1 question will include elements of recall of knowledge directly from thespecification (up to a maximum of 15%). These will be identified by an asterisk in the mark scheme.

QuestionNumberAnswerMark1(a)(i)Bthe lens gets thicker to bend the light raysmore(1)1. The only correct answer is BAO 2 1A is not correct because it would not bend the lightrays more.C is not correct because the light rays need to be bentmore.D is not correct because the light rays need to bebent more.QuestionNumber1(a)(ii)Answerlight rays meet in front of theretina (1)Additionalguidanceaccept eye is toolong/too bigaccept light isrefracted too muchMark(1)AO 1 1QuestionNumber1(a)(iii)AnswerAdditional guidanceMarkconcave /diverging / minus(lens)ignore contact lens(1)AO 1 1QuestionNumber1(b)AnswerAdditional guidance(3)An answer that combines thefollowing points to provide aplan: choose equal numbersof people with brownand blue eyes (1) test their vision /detailsof a method to testvision (1) count the number ofpeople in each groupwho are short-sighted/ifmore people withbrown eyes are shortsighted the hypothesisis correct / ORA (1)MarkAO 3 3aaccept compare theresults for the twogroupsTotal for Question 1 6 marks

QuestionNumber2(a)AnswerAn explanation linking: exercise {requires energy/uses respiration} (1) {obtain from/reducing} fat (1)AdditionalguidanceMarkaccept burnscaloriesAO 1 1(2)accept sweatingcauses waterloss for 1 dditionalguidanceAn explanation linking two of thefollowing: reduces the volume of the stomach(1) so it reduces food intake (1) so stored {fat/lipids} is used up (1)Answersubstitution (1)72 1.812Mark(2)AO 2 1accept restrictsthe amount offood enteringthe stomachAdditionalguidanceaccept 72 3.2761Mark(3)AO 1 1evaluation (1) 21.977 / 21.98 / 22award 2 marks forcorrect evaluation3 s.f. (1)22.0award full marksfor correctnumerical answerwithout workingaccept 21.9 for 2marks

QuestionNumber2(c)(ii)AnswerAdditionalguidance the BMI shows male A isoverweight but his waist:hipratio {shows he is notabdominally obese / is below0.9/is healthy} (1) male A’s weight distribution isnot around the {vitalorgans/abdomen} (1)Mark(2)AO 3 2aAO 3 2baccept male A’sweight isdistributed evenlyover the bodyaccept moreweight on the hipsthan the waistaccept mass forweightTotal for Question 2 9 marks

nNumber3(a)(iii)Answer(2 x 5.0 x 2.0) (2 x 5.0 x 2.0) (2 x 2.0 x 2.0) or 20 20 8 (1)Additionalguidanceallow full marks forcorrect final answer48.0accept 48AnswerAdditionalguidanceaccept chip B isbigger / has morecells chip B has greater surfacearea (1) therefore more water{absorbed / moved intothe potato chip} (1)AnswerAdditional guidance(cells) lose water / becomeplasmolysed (1)followed by (water moves out) byosmosis (1) from a high concentration ofwater molecules (in thepotato) to a lowconcentration of watermolecules (in the solution) /through the partiallypermeable membrane (to thesalt solution) (1)(2)AO 1 1Mark(2)AO 3 2aAO 3 2bMark(3)An explanation that links thefollowing: Markaccept getsmaller/shrink/losemassaccept from lowsolute concentrationto a high soluteconcentrationaccept from high tolow water potentialAO 1 1

QuestionNumber3(b)AnswerAdditionalguidanceAn explanation that links: no chloroplasts (in the potato)(1) (as there is no light) forphotosynthesis / potato cellsdo not photosynthesise / ORA(1)accept fewerchloroplasts/chlorophyll (in thepotato)Mark(2)AO 2 1more amyloplasts /starch grains in thepotato (1)for storage (1)Total for Question 3 9 marks

ifferentiation (1)additionalguidanceMarkacceptspecialisation(1)AO 2 1AnswerMarkA logical description including two ofthe following:(2) many plants produced (1)accept gives moreof that plant/higheryield of that plant quicker than sexualreproduction (1)ignore plants growfaster genetically identical/ clonesproduced (1) with the desiredcharacteristics (1) plants from{endangered/rare} plants (1)obtain plantsdifficult to growfrom seed (1)AO 1 1

onal guidance(2)Any two from: sterilises agar growthmedium (1) destroys iruses} /there is nocontamination (1)ignore preventsmicroorganismsgetting in so microorganisms don’t{affect growth of plantlets /don’t compete withplantlets/ don’t usenutrients needed byplantlets} (1)accept only theplantlets growAnswer mutation / diseaseMarkAO 2 2Additional guidanceMarkaccept different alleles/genotypes/geneticvariation(1)AO 2 1AnswerMarkAn answer that provides a description by makingreference to:(2) add iodine (solution) (1) blue-black colour indicates presence of starch(1)Answer it is an insulator/reducesheat loss (1) so energy from sugar isused to heat water / theresult is more accurate (1)Additionalguidanceaccept stops waterlossAO 1 2Mark(2)AO 2 2

QuestionNumber4(b)(iii)Answer ensures heat isdistributed (evenly)throughout the water (1)Additionalguidanceaccept all the wateris at the sametemperatureMark(1)AO 2 2Total for Question 4 11 marks

QuestionNumber5(a)(i)AnswerAdditional guidanceMark(2)Any two from: wash hands after contact (1) avoid direct contact / wear{gloves/protective clothes} (1) wear a (protective) mask (1) sterilise equipment {before/after} use (1)accept hand gelsAO 2 2accept protect yourfacebe immunised (1)QuestionNumberAnswerAdditional guidance5(a)(ii)subtraction 5943 - 2830 3113 (1)accept 5943 - 2830 28303113 2830 x 100 110%award full marks for correctnumerical answer withoutworkingMark(2)AO 2 1accept other valid methods forthe calculationQuestionNumber5(a)(iii)AnswerMarkA(1)it does not have flagella1. The only correct answer is AB is not correct because plasmids do not allow motility.C is not correct because it does have ribosomes.D is not correct because acrosomes are not found in bacteria.AO 2 1

Question AnswerNumber5(b)D testing using cultured cells testing in healthy volunteers double blind trials on patientsMark(1)AO 1 11. The only correct answer is DA is not correct because the medicine is tested on cultured cellsfirst.B is not correct because double blind trials are used after testingin healthy volunteers.C is not correct because the medicine is tested on cultured cellsfirst.QuestionNumber5(c)AnswerAn answer linking three of the following: exposure to the {toxin/antigen/pathogen/bacteria} (1) stimulates an immune response (1) production of {(B)lymphocytes/antibodies} (1) production of memory lymphocytes dAO 2 1(3)acceptantitoxinsTotal for Question 5 9 marks

ional guidanceMark(3)Any three from: have the potential to produce anycell type (1)accept can turn intomany cell types/pluripotent /totipotent no need to use embryonic stem cells(1)accept embryos do notneed to be killed less chance of patient rejecting theirown cells (1) used to treat conditions which arecurrently incurable / used for celltransplants /used to replace faultycells (1)accept namedconditions e.gParkinson’s / diabetesignore references tocloning body parts /replace organs / treatcancer unless qualifiedAnswerBAO 2 1MarkR Q S P1. The only correct answer is B(1)AO 3 1bA is not correct because Q is after RC is not correct because S is after QD is not correct because R is before Q and SQuestionNumber6(b)(ii)AnswerAMarkanaphase1. The only correct answer is AB is not correct because R is prophaseC is not correct because P is telophaseD is not correct because Q is metaphase(1)AO 3 1a

Question AnswerNumber6(b)(iii) Any two from:Additionalguidance DNA is replicated (1)accept DNAduplicates/chromosomesduplicate production of cell {components/proteins / organelles}(1)accept sub-cellularstructures / namedstructures {metabolic activities / cellreactions} occur / cellgrowth(1)Mark(2)AO 1 1chromosomes coilup / condense (1)QuestionNumber6(c)Answer selection of 40 xobjective lens (1) combines with 10 x eyepiece lens (1)Additional guidanceaccept othercombinations thatmultiply together tomake 400 x with the eyepiece as equal or thelower powerMark(2)AO 1 2accept use two lenseswith correctmagnification to make400x for 1 markTotal for Question 6 9 marks

nNumber7(b)(i)AnswerAdditionalguidance same structure of bones/examplesof bone structure (1) (structure is) unlikely to haveoccurred more than once duringevolution / common ancestor had{the pentadactyl limb structure/similar limb structure} (1)AnswerMark(2)AO 2 1accept unlikely thatdifferent ancestorswould have had thesame structuresAdditionalguidanceMark compare the {genes/sequence ofgenes} from different organisms(1)accept idea ofidentifyingsimilarities anddifferences in the{genes/sequences} closely related organisms have{more similar/identical}sequences /differences insequence can show evolution (1)accept organismswith similar genesequences share acommon ancestor(2)AO 1 1AnswerMarkB(1)phenotype1. The only correct answer is BA is not correct because genotype is the combinationof allelesC is not correct because an allele is an alternativeversion of a geneD is not correct because gametes are sex cellsAO 1 1

QuestionNumber7(b)(ii)AnswerAdditional guidance(3)An explanation linking three of thefollowing: the first generation wereheterozygous (1)accept first generationare carriers offspring {needed twowrinkled alleles/arehomozygous} to have wrinkledseeds (1)accept traits for alleles 25% offspring have wrinkledseeds (1) wrinkled is recessive / round isdominant (1)MarkAO 2 1accept 1 in 4wrinkled seeds arehomozygous recessive 2 marksaccept annotatedPunnett squares/genetic diagramsQuestionNumber7(c)AnswerMarkPhenotype:(3) must be unaffected male (1)AO 3 1bAO 3 2aAO 3 2bExplanation including thefollowing: he has the dominant allele /males have one copy of theallele as is on the Xchromosome (1) (needs a dominant allele) inorder to have an unaffecteddaughter (1)accept XDY(accept any othercapital letter) for1 markaccept a Punnettsquare to showmarking points ifannotated.Total for Question 7 11 marks

QuestionNumber8(a)(i)AnswerMarkB(1)substrate1. The only correct answer is BAO 2 1A is not correct because oxygen and water are theproductsC is not correct because the active site is part of thecatalase enzymeD is not correct because a control would using water andnot hydrogen peroxideQuestionNumber8(a)(ii)Answer Additional guidanceMarkmass is a variable/controlling a variable (1)accept the idea thatdifferent masses wouldneed more or lessoxygen/rise quicker orslower(2)so the results could becompared/equal amountof catalase in eachreaction (1)ignore references tofair test or reliableresultsaccept enzyme forcatalaseAO 2 2

QuestionNumber8(a)(iii)AnswerAny two from:Additionalguidancetemperature (1)volume of hydrogen peroxide(1)ignore amount of hydrogenperoxideaccept mass for volumethe distance the potato had torise (1)pH (1)size of test tube (1)age/variety/type of potato (1)surface area of potato (1)accept all discs from thesame potatothe same stock solution ofhydrogen peroxide (1)Mark(2)AO3 3b

QuestionNumber8(b) (i)AnswerMarkConclusion for 1 mark(4) increasing the concentrationof hydrogen peroxide{increases the rate ofreaction/decreases the timetaken for the disc to rise} (1)AO 3 2aAO 3 2band any three from:QuestionNumber8(b)(ii) provides more substrate (1)accept hydrogenperoxide forsubstrate increases collisions (1) more active sites occupied (1) forming more enzyme-substratecomplexes (1) oxygen is released faster (1)accept moreoxygen releasedAnswerAdditional guidanceMarksubstitution 1 75 0.013333 /0.01 (1)2 marks for correctanswer to 3 decimalplaces with noworking(2)correct number of decimal places0.013 (s-1) (1)QuestionNumber8(b)(iii)AnswerAdditional guidancesubstrate is not the rate limitingfactor/all active sites (ofcatalase) are occupiedaccept the{enzyme/another factor}is the limiting factorAO 2 2Mark(1)AO 2 1Total for Question 8 12 marks

dditional guidance(2)An explanation linking two of thefollowing: cut the {plasmid/gene/DNA}with a restriction enzyme(1) insert the gene into theplasmid using ligase (1) gene and plasmid have thesame sticky ends /complementary sticky ends(1)Answeraccept vector forplasmidAdditional guidance (yeast grows rapidly)increasing yield (1) it can be produced in ashorter time period (1) production is cheaper/easierto extract (1) takes up less space thangrowing plants (1) yeast growth is not weatherdependent (1)At least one from risks concerns over the geneticallymodified yeast beingmanufactured illegally (1) the painkillers may not beidentical/as effective (1) concerns over GM organismsentering environment (1)AO 1 1Mark(3)An evaluation that combines threeof the following points:At least one from benefitsMarkMax of 2 marks forbenefits.Max of 2 marks for risks.accept possible healthrisks of painkillers fromGM yeastAO 2 1

Question AnswerNumber9(b)(i)Csugar1. The only correct answer is CA is not correct because the base is the rectangleB is not correct because the phosphate is the circleD is not correct because a polymer is composed of repeatedsubunitsMark(1)AO 1 1

QuestionNumber*9(b)(ii)Indicative contentMarkAnswers will be credited according to candidate’s deployment ofknowledge and understanding of the material in relation to thequalities and skills outlined in the generic mark scheme.(6)AO 1 1The indicative content below is not prescriptive and candidatesare therefore not required to include all the material that isindicated as relevant. Additional content included in theresponse must be scientific and relevant. LevelLevel 1Mark01–2Level 23–4Level 35–6DNA sequencesDNA has 4 different baseschanges in the DNA are mutationsresults in different alleles for these genesaffects the phenotype / produces variationOutcome of DNA sequencing for the individualidentify genetic diseasesidentify the risk of developing diseasesimpact of knowing that a disease could developallow the individual to modify their lifestyle to reduceriskImpact on medical treatmentHGP has determined the location of genes/determined thefunction of proteinswe have a better understanding of some diseasestake preventative medicineprovide tailor-made medical treatments/personalisedmedicinesDescriptorNo rewardable material. Demonstrates elements of biological understanding, someof which is inaccurate. Understanding of scientific ideaslacks detail. (AO1) Presents an explanation with some structure andcoherence. (AO1) Demonstrates elements of biological understanding, whichis mostly relevant but may include some inaccuracies.Understanding of scientific ideas is not fully detailed and/ordeveloped. (AO1) Presents an explanation that has a structure which is mostlyclear, coherent and logical. (AO1) Demonstrates accurate and relevant biologicalunderstanding throughout. Understanding of the scientificideas is detailed and fully developed. (AO1) Presents an explanation that has a well-developed structurewhich is clear, coherent and logical. (AO1)Total for Question 9 12 marks

Question AnswerNumber10(a)(i) spread {each bacterial species/thebacteria} on a different agar plate, addmyxopyronin discs and incubate theplates (1) {measure / compare} the zone ofinhibition (1)Question AnswerNumber10(a)(ii) An explanation that links four of thefollowing:AdditionalguidanceMark(2)accept filter discs formyxopyronin discsAO 1 2accept descriptions ofa zone of inhibitionAdditionalguidance antibiotics destroy bacteria /preve

Mark Scheme (Results) Summer 2018 . Pearson Edexcel GCSE . In Biology (1BI0) Paper 1H Paper 1 . Edexcel and BTEC Qualifications . Edexcel and BTEC qualifications are awarded by Pearson, the UK’s largest awarding body. We provide a wide range of qualifications including academic, vocational,

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