29th Annual Conference Clinical Hematology & Oncology

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29th Annual Conference Clinical Hematology & Oncology Saturday, February 14 Tuesday, February 17, 2009 Omni Hotel San Diego, California

Course Information Dear Colleague, Scripps Cancer Center’s 29th Annual Conference: Clinical Hematology and Oncology 2009 is designed for hematologists, oncologists, surgeons, radiation oncologists, internists, and others desiring an update in these specialty areas. The program focuses on selected hematologic subjects the first day, hematologic malignancies the second day, new developments in oncology with a focus on issues of current interest the third day and breast cancer the final day. This year, we are also pleased to offer a dinner symposium discussing prostate cancer. Afternoon workshop sessions will be offered focusing on topics in hematology and coagulation. All presenters will discuss their approaches to challenging but common clinical situations and there will be ample time for participant interaction. The primary objective of this course is to bring together clinicians and leading experts in diverse areas of hematology and oncology, affording them an intimate environment in which to discuss new clinical developments and significant advances. We are honored to have two lectureships showcased at the meeting this year. Dr. Ron Natale will present the Dr. Robert Memorial Longmire Lecture. Dr. Longmire was a valued member of Scripps Clinic and this lectureship has been established in his memory. The honoree of the prestigious 29th Annual Bernard L. Schwartz Lecture will be Dr. Clifford Hudis. Dr. Hudis will be speaking on Triple Negative Breast Cancer. A glance at the agenda will reveal we have been most fortunate to assemble an outstanding faculty for this meeting. We look forward to seeing many past participants again in 2009 and invite to San Diego those of you who have not previously had the opportunity to attend this excellent conference. Michael P. Kosty, M.D., F.A.C.P. Course Director Educational Objectives After participating in this course, the attendee should be able to: Describe the pathogenesis, diagnostic approaches and therapeutic modalities available for hematologic disorders discussed; Summarize the changing approaches to hematologic malignancies including innovations in diagnosis and treatment; Recognize and list new therapeutic options for the treatment of a number of common cancers; Evaluate the evolving approaches to breast cancer; and Apply practical experience in the clinical situations discussed in the workshop sessions. Accreditation Disclosure Cultural and Linguistic Competency Scripps Clinic is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. It is the policy of Scripps Clinic to ensure balance, independence, objectivity, and scientific rigor in all sponsored educational programs. Course Directors, planning committees, faculty and all others who are in a position to control the content of any educational activity sponsored by Scripps Clinic are required to disclose any real or apparent conflicts of interest related to the subject matter of the educational activity. This activity is in compliance with California Assembly Bill 1195 which requires that all CME activities comprising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic concerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity. Scripps Clinic designates this educational activity for a maximum number of 27 AMA PRA Category 1 Credit(s) . Physicians should only claim credit commensurate with the extent of the participation in the activity. Saturday Sunday Monday Tuesday 7.5 credits (includes workshops) 7.5 credits (includes workshops) 7.5 credits (includes evening symposium) 4.5 Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course. Educational Grants This course is supported, in part, by educational grants from industry, in accordance with ACCME Standards. At the time of printing, a complete listing of commercial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity.

Faculty Course Director Michael P. Kosty, M.D., F.A.C.P. Medical Director, Scripps Green Cancer Center Director, Graduate Medical Education Scripps Clinic/Scripps Green Hospital La Jolla, California Scripps Faculty Jeffrey Andrey, M.D. Division of Hematology & Oncology Blood and Marrow Transplantation Scripps Clinic La Jolla, California Joan Kroener, M.D. Director, Breast Program Scripps Clinic La Jolla, California James Mason, M.D. Director, Scripps Clinical Research and Continuing Medical Education Director, Scripps Blood and Marrow Transplant Program Scripps Clinic La Jolla, California William Miller, M.D. Associate Professor Department of Molecular & Experimental Medicine The Scripps Research Institute La Jolla, California Alan Saven, M.D. Head, Division of Hematology & Oncology Scripps Clinic La Jolla, California Darren Sigal, M.D. Division of Hematology & Oncology Scripps Clinic La Jolla, California James Sinclair, M.D. Medical Director, Stevens Division Scripps Cancer Center La Jolla, California William Stanton, M.D. Medical Director, Scripps Cancer Center Mercy Hospital San Diego, California Angela DeMichele, M.D., M.S.C.E. Assistant Professor, Medicine and Epidemiology Co-leader, Breast Cancer Program, Abramson Cancer Center Senior Scholar, Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia, Pennsylvania Terry Gernsheimer, M.D. Associate Professor University of Washington School of Medicine Division of Hematology Pudget Sound Blood Center Seattle, Washington Morie Gertz, M.D. Chair, Department of Medicine Mayo Clinic Rochester, Minnesota John Godwin, M.D., M.S. Professor of Medicine Chief, Division of Hematology/Oncology and Associate Director Simmons Cooper Cancer Institute Southern Illinois University School of Medicine Springfield, Illinois Daniel Haller, M.D. Professor of Medicine University of Pennsylvania Abramson Cancer Center Philadelphia, Pennsylvania Sandra Horning, M.D. Professor of Medicine Oncology and Blood and Marrow Transplantation Stanford University Medical Center Stanford, California Clifford Hudis, M.D. Chief, Breast Cancer Medicine Service Memorial Sloan-Kettering Cancer Center New York, New York Hagop Kantarjian, M.D. Chairman and Professor Leukemia Department M.D. Anderson Cancer Center Houston, Texas Guest Faculty Neil Kay, M.D. Profesor of Medicine Mayo Clinic Rochester, Minnesota Paul Chapman, M.D. Member and Attending Physician Melanoma / Sarcoma Service Memorial Sloan-Kettering Cancer Center New York, New York Krystyna Kiel, M.D. Associate Professor Northwestern University School of Medicine Savannah, Georgia E. David Crawford, M.D. Professor of Surgery, Urology, and Radiation Oncology Head, Urologic Oncology University of Colorado Denver Aurora, Colorado John Kelton, M.D. Professor, Pathology and Molecular Medicine Dean and Vice-President Faculty of Health Sciences McMaster University Hamilton, Ontario Ann Mohrbacher, M.D. Associate Professor of Clinical Keck School of Medicine University of Southern California Los Angeles, California Stephan Moll, M.D. Associate Professor Department of Medicine Division of Hematology-Oncology University of North Carolina School of Medicine Chapel Hill, North Carolina Barbara Murphy, M.D. Director, Pain & Symptom Management Clinic Leader, Head & Neck Research Team Vanderbilt Ingram Cancer Center Nashville, Tennessee Ron Natale, M.D. Attending Physician Director, National Lung Cancer Research Program Cedars-Sinai Medical Center Los Angeles, California Ruth O'Regan, M.D. Assistant Professor Director, Translational Breast Cancer Research The Emory Clinic Atlanta, Georgia Kornelia Polyak, M.D., Ph.D. Associate Professor of Medicine Dana-Farber Cancer Institute Boston, Massachusetts Derek Raghavan, M.D., Ph.D. Director, Cleveland Clinic Taussig Cancer Institute Cleveland, Ohio Christy Russell, M.D. Associate Professor of Medicine University of Southern California Los Angeles, California Oliver Sartor, M.D. Piltz Endowed Professor of Cancer Research Departments of Medicine and Urology Tulane Medical School New Orleans, Louisiana Neil Shah, M.D., Ph.D. Assistant Professor, Division of Hematology/Oncology The UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California Susan Slovin M.D., Ph.D. Associate Attending Physician, Genitourinary Oncology Service Memorial Sloan-Kettering Cancer Center Associate Professor of Medicine, Department of Medicine Weill Medical College of Cornell University New York, New York Wendy Stock, M.D. Professor of Medicine University of Chicago Chicago, Illinois Alexis A. Thompson, M.D., M.P.H. Director of Hematology Services Associate Professor of Pediatrics Northwestern University's Feinberg School of Medicine Chicago, Illinois

Program Friday, February 13 4:00 to 6:00 pm Pre-Registration & Welcome Refreshments Course attendees, faculty & guests are invited to attend. Saturday, February 14 Sunday, February 15 Malignant Hematology Moderator James Mason, M.D. 7:00 a.m. Continental Breakfast & View Exhibits 8:00 a.m. Practical Strategies for the Application of Novel Agents in the Frontline Treatment of Multiple Myeloma Ann Mohrbacher, M.D. 8:45 a.m. Treatment Options for the Patient with Amyloidosis Morie Gertz, M.D. 9:30 a.m. Break & View Exhibits Nonmalignant Hematology Moderator William Stanton, M.D. 7:00 a.m. Registration, Continental Breakfast & View Exhibits 7:50 a.m. Welcome & Introduction Michael Kosty, M.D. 8:00 a.m. New Developments in Diagnosing and Treating ITP John Kelton, M.D. 8:45 a.m. Therapeutic Options for the Patient with Non-Immune Thrombocytopenia Terry Gernsheimer, M.D. 9:30 a.m. Break & View Exhibits 10:00 a.m. Hematologic Aspects of Pregnancy Stephan Moll, M.D. 10:00 a.m. Nodular Lymphocyte-Predominant Hodgkin Disease Sandra Horning, M.D. 10:45 a.m. Approach to the Patient with Imatinib-Refractory CML Neil Shah, M.D. 11:30 a.m. New Options for a Patient with MDS Hagop Kantarjian, M.D. 12:15 p.m. Lunch Moderator Alan Saven, M.D. 1:15 p.m. New Options for a Patient with Mantle Cell Lymphoma Sandra Horning, M.D. 2:00 p.m. Comprehensive Management of the CLL Patient Neil Kay, M.D. 2:45 p.m. Controversies in the Treatment of AML: A Case-based Discussion Wendy Stock, M.D. 1:15 p.m. The Bleeding Patient Who Clots Stephan Moll, M.D. 3:30 p.m. Break & View Exhibits 2:00 p.m. Thrombophilia: Common Questions on Laboratory Assessment & Management John Godwin, M.D. 4:00 p.m. Workshops 5:30 p.m. Adjourn 10:45 a.m. Hemoglobin E Syndromes Alexis Thompson, M.D. 11:30 a.m. Potpourri: Patient-based Clinical Problems John Kelton, M.D. 12:15 p.m. Lunch Moderator Jeffrey Andrey, M.D. 2:45 p.m. What is a Cryoglobulin and Why Should I Care? Morie Gertz, M.D. 3:30 p.m. Break & View Exhibits 4:00 p.m. Workshops 5:30 p.m. Get Acquainted Reception Omni Hotel Course attendees, faculty and guests are invited to attend. Saturday & Sunday Workshops A B C D E Clinical Problems in Hematology I: Case-based Clinical Discussions John Kelton, M.D. Clinical Problems in Hematology II: Case-based Discussions Focusing on Terry Gernsheimer, M.D. Clinical Problems in Hematology III: Case-based Discussions Focusing on Morie Gertz, M.D. Clinical Problems in Coagulation I: Case-based Discussions Focusing on Stephan Moll, M.D. Clinical Problems in Coagulation II: Case-based Discussions Focusing on John Godwin, M.D. Platelet Abnormalities Anemias Bleeding Clotting

Program Monday, February 16 Tuesday, February 17 State of the Art: Therapy of Cancer Focus on Breast Cancer 7:00 a.m. Continental Breakfast & View Exhibits 7:00 a.m. Continental Breakfast 8:30 a.m. The Biology of Melanoma & Current Therapeutic Options Paul Chapman, M.D. 8:00 a.m. Risk Prediction for Breast Cancer Ruth O’Regan, M.D. Approaches to the Patient with Advanced Bladder Cancer Derek Raghavan, M.D. 8:45 a.m. 9:15 a.m. Breast Cancer Stem Cells: Fact or Fiction? Kornelia Polyak, M.D. 9:30 a.m. S C H WA R T Z L E C T U R E S H I P : Moderator William Miller, M.D. Moderator Joan Kroener, M.D. 10:00 a.m. Break & View Exhibits 10:30 a.m. Strategies for the Patient with Recurrent Colon Cancer: Individualizing Therapy Daniel Haller, M.D. 11:15 a.m. LONGMIRE L E C T U R E S H I P : A Rational Approach to the Patient with Advanced Lung Cancer Ron Natale, M.D. 12:00 p.m. Lunch State of the Art: Supportive Oncology Triple Negative Breast Cancer Clifford Hudis, M.D. 10:15 a.m. Break 10:30 a.m. Why Can’t We Cure Metastatic Breast Cancer? Angela DeMichele, M.D. 11:15 a.m. Targeted Options for the Patient with Breast Cancer Christy Russell, M.D. 12:00 p.m. Radiotherapy of Breast Cancer: Is Less More? Krystyna Keil, M.D. 12:45 p.m. Final Adjournment Moderator Darren Sigal, M.D. 1:00 p.m. Improving Cancer Pain Management Barbara Murphy, M.D. 1:45 p.m. Cognitive Impairment in Cancer Patients TBD 2:30 p.m. Integrating Supportive and Palliative Care into Oncologic Patient Care TBD 3:15 p.m. Break Dinner Symposium: Prostate Cancer Moderator Michael Kosty, M.D. 3:45 p.m. Preventing Prostate Cancer: Update 2009 E. David Crawford, M.D. 4:30 p.m. Do We Over Treat Prostate Cancer? Oliver Sartor, M.D. 5:15 p.m. 2009 Options for the Hormone-Refractory Patient Susan Slovin, M.D. 6:00 p.m. Dinner: The Ultimate Skybox at Diamond View Tower The Ultimate Skybox is located just a few short blocks from the Omni Hotel on the top floor of Diamond View Tower, which sits just outside the right-field fence of Petco Park. The Ultimate Skybox has breath taking views of the San Diego skyline, San Diego Bay, Coronado Island and looks directly into Petco Park. You and one guest are welcome to attend, please be sure to RSVP for this event on the registration form! You will receive tickets to attend this dinner once you check-in with the Scripps Registration Desk at the conference.

Conference Location & Hotel Information OMNI SAN DIEGO HOTEL The Omni San Diego Hotel, a 32-story luxury hotel, opened in the spring of 2004 and is connected via skybridge to PETCO Park, the San Diego Padres Ballpark. Nestled in the heart of the historic Gaslamp Quarter, the hotel is just moments away from the city’s top sites and attractions - including beaches, parks, museums and theaters. Take in the extraordinary views of the San Diego Bay, the downtown skyline or ballpark from the comforts of your guest room, or enjoy the sun-soaked outdoor terrace which features a pool, spa and fireplace. Accommodations Relax in the privacy of San Diego's finest hotel accommodations. The Omni San Diego Hotel features over 500 elegant guest rooms and suites which are decorated in a luxurious, contemporary style and feature the most modern amenities. The accommodations will welcome you with California warmth and sophistication throughout your stay. Hotel Amenities Transportation The Omni San Diego Hotel is a short 4 miles (10 minute cab ride) from the San Diego International Airport. San Diego offers many options for transportation including the San Diego Trolley, easy accessible cabs or stop by the Concierge desk to have them arrange transportation for you. Dining Whether you’re searching for a light breakfast, an elegant dinner, or a cozy meal in your room, you can find just the right menu option at the Omni. Restaurants located on property are McCormick & Schmick’s Seafood Restaurant, Morsel’s, and the Terrace Bar & Grill. Guest room dining is also available 24-hours and all items are prepared by the culinary team of McCormick & Schmick’s. Local Area The Omni is just steps away from the historic Gaslamp Quarter, one of San Diego’s most historic areas with century-old Victorian buildings, eclectic restaurants, shops, art galleries, and night clubs. Horton Plaza, a seven-block mall, just a short walk from the Omni, features a wide-variety of shops and restaurants. Seaport Village, a seaside village featuring one-of-a-kind shops, restaurants and sidewalk eateries is located on the water just one half-mile away. Two miles from the hotel is Balboa Park, the cultural center of the city, featuring 12 distinctive museums, beautiful gardens, and the World Famous San Diego Zoo. Complimentary Hi-Speed Wireless & Wired Internet Access Complimentary Fitness Center Get Fit Kits & Get Fit Guestrooms Outdoor heated pool & spa DVD player in each room Spa Treatment Room Full Service Concierge Omni Kids Program Express Check-in & Check-out Rates & Reservations Please make your own hotel reservations. Make sure to mention the Scripps conference when requesting the especially low rate of 235 per night (excludes tax). Make your reservations early! A block of rooms will be held for Scripps until January 22, 2009. After this time, reservations will be accepted on a space and rate available basis only. Omni San Diego Hotel 675 L Street San Diego, CA 92101 Reservations: (619) 231-6664 Fax: (619) 231-8060 Web: www.omnisandiegohotel.com (enter the group code 17300101639 for online reservations) Discounted Scripps Rate: 235/night

Clinical Hematology & Oncology 2009 Registration &Information Conference Registration Included: continental breakfasts, coffee breaks, lunches, receptions, the Monday Dinner Symposium, the course syllabus and CD-ROM. Full Conference: . 600 Physicians . 350 Fellows/Residents/Others . 250 Physicians . 175 Fellows/Residents/Others To Register Day Rate: Sat Sun Mon Tue (circle one) Sat Sun Mon Tue (circle one) Saturday & Sunday Workshops Circle your first and second choices for workshops. Workshops are filled on a first-come, first-serve basis. Saturday 1st Choice: A B C D E 2nd Choice: A B C D E 1st Choice: A B C D E 2nd Choice: A B C D E Sunday Monday Dinner . Will be attending . Will be attending with one guest Conference Course Materials If you are unable to attend the conference the course materials are available for purchase. . 150 Printed Syllabus & CD-ROM which contains the final presentations/audio of program Online Fax Phone Mail Questions? Contact Scripps Conference Services & CME Phone (858) 652-5400 Email med.edu@scrippshealth.org Help Us Improve Our Conference 1. Please print clearly. Your badge will read as follows: www.scripps.org/conferenceservices (858) 652-5565 (858) 652-5400 Scripps Conference Services & CME Hem/Onc Conference 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, CA 92037 Please indicate your primary institutional affiliation. Private Practice F i r s t , MI , L a s t N a m e D e g r e e ( M . D . , DO , P h D , e t c ) Hospital/Clinical Facility Corporate (Biochem or Pharmaceutical) H o s p i ta l / A f f i l i at i o n Medical School Other: . street address C i t y S t a t e / P r o v i n c e 2. zip code Please indicate your primary job responsibility. Direct Patient Care Office telephone Research fax Teaching Administration email s p e c i a l n e e d s , i n c l u d i n g d i e ta ry r e s t r i c t i o n s Payment Method 3. Types of Cancers/Disorders you treat/research (check all that apply). Cancer Check Please make checks payable to Scripps .Visa Other: . . MasterCard . Amex Breast Cancer . Discover If paying by credit card, please complete information below Colon and Rectum Cancer Head and Neck Cancers Hematologic Disorders name on card card number e x p i r a t i o n d a t e Office Use Only Melanoma Multiple Myeloma Myelodysplasia Hodgkin’s/Non-Hodgkin’s Lymphoma credit card billing address (if different from above) Refund, Substitution and Cancellation Policy The course tuition is refundable, minus a 100 processing fee, if your cancellation is received in writing no later than February 6, 2009. Attendee substitutions are allowed, but notification must be made in writing by February 6, 2009. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to “no shows.” Scripps reserves the right to cancel this conference, in which case a full refund of your registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation. Leukemia Lung Cancer s i g n at u r e Recording and Photography Clause Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales. Onsite Registration Fee Clause Please note: pre-registration will be accepted through February 10, 2009. After this date, registrations will only be accepted on-site and will incur an additional 25 fee. Ovarian Cancer Prostate Cancer Other: . . D ate received C heck no / A pproval CD A mount C onfirmation Sent Initials

Scripps Cancer Center's 29th Annual Conference: Clinical Hematology and Oncology 2009 is designed for hematologists, oncologists, surgeons, radiation oncologists, internists, . Scripps Clinic/Scripps Green Hospital La Jolla, California Scripps Faculty Jeffrey Andrey, M.D. Division of Hematology & Oncology Blood and Marrow Transplantation

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