NEEMMC GUIDELINES FOR TABLET CRUSHING

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NEEMMC GUIDELINES FOR TABLET CRUSHINGAND ADMINISTRATION VIA ENTERAL FEEDING TUBESKEY TO DRUG ADMINISTRATION GUIDELINESPlease follow the guidelines in order, as shown in the chart (i.e. number 1 is the first choice ofwhich form to administer the drug in).ABCDETablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non SterilePreparative Services (PSU at Colchester General Hospital, Tel: 01206 745962).Note: It is an unlicensed use to crush tablets, open capsules and makeextemporaneous suspensions.These guidelines should not be used as a means to covertly administer medication. Allmedication must only be given with full patient consent; if covert administration isconsidered to be in the best interests of the patient, due regard must be paid to allrelevant legislation (Mental Capacity Act 2005, Mental Health Act 1983 as amended in2007).For more information on the administration via different tubes,please contact Medicines Information on ext. 2161.DrugKey codeACETAZOLAMIDE1. A2. DACICLOVIR1. C2. A*Diamox 250mg tablets disintegrate veryquickly in 10ml of water.Diamox injection 500mg can be given via afeeding tube.* Dispersible tablets availableALENDRONIC ACIDALFACALCIDOL1. C*2. DALFUZOSINAABCDEInformationCaution: Alendronic acid tablets shouldonly be crushed and dispersed in water ifadministered via a feeding tube, NOT orally(very irritant). Once-weekly formulationshould be used.* Oral drops available (1 drop 100nanograms).One-Alpha injection can be administeredorally or via a feeding tube.Beware of sudden hypotensive effect ifgiving crushed tablets. Monitor BP andensure patient is lying down prior toadministering the dose.Do not crush slow release preparations.Tablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-1-Updated April 2012Review April 2013

ALLOPURINOL1. B2. EALVERINEAMANTADINEAMILORIDEContent of capsules is very bitter, andmight numb the tongue and throat.* Capsules may be opened and contentsdispersed in water.1. C2. A*1. B2. C** Oral solution available.Convert to theophylline: Slo-Phyllin MRcapsules can be opened and pellets can betaken orally or via a tube. Do not BIC ACIDASPIRINAAATENOLOL1. C2. CBETablets do not disperse readily but can becrushed and dispersed in water.Orodispersible tablets available.* Normal tablets can be crushed, mixedwith water and taken immediately. Someexcipients are insoluble in water and mayfloat to the surface.(Bristol Myer Squibb .2.ABEffervescent tablets available.Convert enteric coated tablets todispersible aspirin.Most tablets are film coated, which do notdisperse readily in water. Film coat mayclog tube.A*ECB* Do not crush tablets. Cytotoxic, weargloves.Capsules can be opened and sprinkled inwater or on food. Capsule contents willstain.BEBESoluble tablets available.Do not crush MR forms (Bezalip Mono ),change to equivalent dose of normalrelease tablet and crush (bezafibrate MR400mg OD equivalent to bezafibrate200mg TDS).Tablets can be crushed, but are practicallyinsoluble in water.BICALUTAMIDEABCDETablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-2-Updated April 2012Review April 2013

BISACODYLBISOPROLOLBROMOCRIPTINEBUMETANIDETablets are enteric coated. Crushed tabletsare very irritant. Use suppositoriesSome brands may need to be crushed.Also, capsules can be opened.BA1. B2. DBUPROPIONTablets are slow release and should not becrushed (increased risk of adverse effectsincluding seizures).(Ref. GlaxoSmithKline, Zyban SPCs, Jan 09)BUSPIRONECABERGOLINECALCIUM RESONIUMBBCALCIUM SALTSCALCIUM FOLINATEA1. B2. ILOLCELECOXIBBCETIRIZINECHLORAL MCLARITHROMYCINABCDE1.2.3.B1.2.When mixed with water, the resulting pasteis too thick to administer via a feeding tube.Rectal route should be used (dose 30g).Effervescent tablets available.Tablets need to be crushed.* Pharmacia and Mayne brands ofinjections can be administered orally.BEC*A* Suspension may bind to PVC feedingtubes. Dilute in water to prevent this.Do not crush slow release preparations.Suppositories can be used for 7 days(when changing from oral to suppositories,the dose must be increased by 25%).Monitor blood pressure.Contents of capsule can be mixed withwater, pudding or apple sauce.CACB** Risk of sensitization. Wear gloves ifcrushing tablets.Interact with PVC feeding tubes, so dilutethe dose in equal amount of water. Monitorplasma levels.Can be mixed with orange or apple juice toimprove taste.* Stop enteral feed prior to administration.Flush tube before and after.Effervescent tablets available.C*ADC*B* Do not dilute suspension further.Stop enteral feed prior to administration.Flush tube before and after.Drops available (4 drops 8mg liquid isequivalent to 10mg tablet).Suspension and sachets are available.1. C2. BCTablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-3-Updated April 2012Review April 2013

CLONIDINECLOPIDOGRELCLOZAPINECO-AMILOFRUSECapsules can be opened and mixed withwater or food.1.2.B1.2.1.2.3.1.AERef. Wockhardt Medical InformationAEAC*EA (Catapres)B (Dixarit)2. IMOXAZOLECYCLIZINECYCLOPHOSPHAMIDEBACB1. E2. SONEDIAZEPAM1.2.1.2.BEAECA*Crush tablets and give with water or infood.Or change to amiloride liquid andfurosemide liquid.* Dispersible tablets available (not kept atCHUFT).Dispersible and effervescent tabletsavailable.* Cytotoxic, wear gloves.Open capsule and disperse contents inwater.CBC*BADIGOXIN1. C2. BC1. B*ABCDE* Dilute and administer Catapres injections.Dispersible tablets available.Do not disperse slow-release tablets.No liquid/dispersible tablets available.Convert to dihydrocodeine liquid andparacetamol liquid.DICLOFENACDIHYDROCODEINEDILTIAZEMCapsules can be opened and contentsmixed with water.* Unlicensed special.*Interact with PVC feeding tube, so dilutedose of suspension with equivalent amountof water.Suppositories and injections available.Dispersible tablets available. Do not crushenteric-coated or slow-release tablets.Suppositories also available.* Open slow-release capsule and disperseTablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-4-Updated April 2012Review April 2013

2. EDIPYRIDAMOLEDOCUSATE 4.C1.2.BBcontent in water. Do not crush the pellets.Do not crush slow-release tablets.Tablets may be crushed.Slow-release capsules may be opened andgranules dispersed in water. Do not crushgranules.CBDECBSuppositories are also available.Crush tablet before suspending in waterCrush tablets and disperse in water. Riskof blocking tubes.Do not crush modified release tablets.Change to normal release.Capsules may be opened and the contentsmixed with water.* Dispersible tablets available.Do NOT open capsules as the contents areirritant.Do NOT open capsules as the contents areirritant. Change to finasteride (see below).1. A2. E1. B2. EBCaution: will stain surrounding objectsorange. Wear gloves.Tablets can be crushed and mixed in applesauce. (Ref. Pfizer)Erythromycin ethylsuccinate is the onlyliquid preparation available. Whenswitching from erythromycin stearatetablets, the dose has to be doubled.Tablets can be crushed and dispersed inwater, orange or apple juice. Bitter taste.To be taken HAMBUTOLETIDRONATE DISODIUMBBEZETIMIBEFERROUS SULPHATEBB or:FEXOFENADINEFINASTERIDEBBFLAVOXATEEB1. A2. EC(Ref. Lundbeck Medical Information)FLECAINIDEFLUCLOXACILLINABCDEStop enteral feed 2 hours before and afteradministration. Flush tube before and after.Switch to sodium feredetate liquid –Sytron (10ml equivalent to 200mgferrous sulphate tablet).Modified release iron tablets should bechanged to the equivalent normal releasestrength and dose first.Wear gloves- Not to be handled by womenwho are or might be pregnant.Tablets are very hard to crush.Stop enteral feed 30min to 1h before andTablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-5-Updated April 2012Review April 2013

FLUVASTATINBFOLIC ACID1.2.1.2.CFUROSEMIDEFUSIDIC ACID/SODIUM FUSIDATEGABAPENTINGALANTAMINEafter administration. Flush tube.Or capsules can be opened and contentsmixed with water.Or capsules can be opened and dispersedin water.Open capsules and disperse in water.Do not open slow-release capsulesCBCA500mg sodium fusidate tablet is equivalentto 750mg oral suspension.Open capsule and disperse in water.Tablets dissolve in water.Slow-release capsules can be opened andcontents mixed with water, orange juice oryogurt. Do not crush.1. C2. A(Ref. Shire Pharmaceuticals Ltd Medical itor blood glucose levels.Monitor blood glucose levels.Tablets disperse in water.The injection can be given orally.Tablets are not soluble in water.Or open capsule and disperse contents YDROXYZINEHYOSCINE EABCDECapsules can be opened and contentsdissolved in water. Take immediately.Caution: Cytotoxic – wear gloves.1.2.1.2.1.2.DBECBBD1.2.1.2.CB*BEInjection can be given orally, no dilutionneeded.Transdermal patches also available.Granules are available.* Do not crush enteric-coated preparations.Tablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-6-Updated April 2012Review April 2013

INDAPAMIDE1. B2. IDEMONONITRATE1.2.1.2.ISOSORBIDE DINITRATEEITRACONAZOLELABETALOLC1. B2. DAALAMOTRIGINELANSOPRAZOLEDo not crush slow release formulations,change normal release (1.5mg SR OD isequivalent to 2.5mg OD).Suppositories are available.Practically insoluble in water. Crush tabletsand give with water or in food.BCBEDo not crush slow release formulations.Change to normal release preparationsand increase frequency to BD. Monitorblood pressure.Patches are available.Or change to isosorbide mononitrate andcrush tablets.Dispersible tablets available.Oro-dispersible tablets available.Capsules can be opened and granulesmixed with 8.4% sodium bicarbonate.Tablets do not dissolve in water. They canbe broken into pieces and taken with food.Consider an alternative (amlodipine).Tablets can be crushed and mixed withwater.Solution available is bitty and can clogtubes.Tablets can be crushed and dispersed inwater or sprinkled on food. Taste bitter.Tablets can be given rectally.(Ref. UCB Pharma)Stop enteral feed prior to administration.Flush tube before and after. Do not use lowdoses.LERCANIDIPINELEVAMISOLEBLEVETIRACETAM1. C2. ELOPERAMIDEABCDETablets can be given rectally.Tablets are slow release, so liquidpreparation may have to be given morefrequently. Monitor plasma lithium levels.Lithium carbonate 200mg lithium citrate509mgOr open capsule and disperse contents inwater.Tablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-7-Updated April 2012Review April 2013

TEMEBEVERINE1. A2. D*3. EA*MEDROXYPROGESTERONE* Injection can be given sublingually.CBBECrush tablets as they are not easily solublein water.Do not crush Circadin tablets.Suppositories are available andbioequivalent to tablets.* Pentasa tablets disperse in water togive MR granules. Do not crush Asacol tablets, they are enteric-coated.Rectal preparations available.For oral administration, the contents of aninjection can be taken in a flavoured drink(orange juice or cola)Sachets available.Monitor blood glucose 2.1.2.1.2.1.2.BCBE1.2.A1.2.ACDCytotoxic – wear gloves, handle with care.CBBEEBCBSuppositories also available.The capsules can be pierced and thecontents mixed with water or sprinkled ontofood. (Ref. Alliance Pharmaceuticals)Injection can also be given rectally.ACMONTELUKASTMORPHINEA1. C2. A*MOXONIDINEAABCDEDo not crush slow release formulations.Soltabs melt on the tongue. They alsodisperse in water.Poor stability. Consider changing toranitidine or lansoprazole.Unstable in water, so give immediately.* MST Continuous sachets available.Do not crush slow release formulations.Zomorph and MXL capsules can beopened. Do not crush the granules.Tablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-8-Updated April 2012Review April 2013

MULTIVITAMINSMYCOPHENOLATE MOFETILNAFTIDROFURYL1. C*2. BCNAPROXEN1. B2. BOLANZAPINE1. A *2. B **OLSALAZINEBOMEPRAZOLE1. B2. PHENADRINEOSELTAMIVIROXPRENOLOLABCDE* Abidec (contains arachis oil) and Dalivitdrops available.Do not crush tablets - teratogenic.Capsule contents can be used but cancause severe irritation/anaesthetic effecton oesophagus. Can be given via PEG orNG tube with plenty of water.Do not crush slow release or entericcoated formulations. Suppositories areavailable.Crush or disperse Adalat Retard tabletsin water and use immediately as lightsensitive.Do not crush Adalat LA tablets- convertto equivalent dose of Adalat retard .* Use immediately as very light-sensitive.B*ECBBCDo not crush slow release formulations.Open capsule and disperse contents inliquid. Consider changing to ranitidineliquid/effervescent.Consider switch to Ciprofloxacin (needsMicro approval).* Orodispersible tablets (Velotabs).** Dissolve in water, apple and orangejuice, milk, or coffee. Wear gloves as veryirritant to skin. Protect eyes. (Ref. Lilly))Capsule contents can be dissolved inWARM water. Contents stain.Losec Mups disintegrate into smallgranules.Losec capsules can be opened and thegranules flushed down the enteral tube.Melt tablets available.CACBCECapsules can be opened and contentsmixed with sweetened food product(chocolate syrup, honey, sugar dissolved inwater, dessert toppings, sweetenedcondensed milk, apple sauce or yogurt) tomask the bitter taste. The mixture shouldbe stirred and taken immediately. (Roche Ltd)Do not crush slow release preparations.BTablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton-9-Updated April 2012Review April 2013

OXYBUTYNINOXYCODONEOXYTETRACYCLINEPANCREATIC .2.BCB1.2.1.2.BCACCBControlled drug.EBOpen capsule (Creon , Nutrizyme ) anddisperse contents in water. Granules mustnot be crushed.Dispersible tablets available.Suppositories also available.Stop enteral feed prior to administration.Flush tube before and after. Avoid lowdoses.PHENYTOINBAB1. C2. BCPHYTOMENADIONE(Vitamin K)PIMOZIDEPIOGLITAZONEPIROXICAM1. B2. D*BBAPIZOTIFENPOTASSIUMC1. A2. CBPRAMIPEXOLEPatches are also available.Consider an alternative.90mg phenytoin suspension is equivalentto 100mg tablet or capsule. Stop enteralfeed 2 hours before and afteradministration. Flush tube with 60ml ofwater after phenytoin. Monitor plasmaconcentration.* Use Konakion MM Paediatric injectionand give orally.Tablets are relatively insoluble. Crush.Dispersible tablets available. Dissolve in atleast 50ml of water as very irritant.Do not crush capsules.Sando K effervescent tablets available.Kay-Cee-L syrup available.Light sensitive, give immediately.(Ref. Boehringer Ingelheim EPROMETHAZINEABCDEVery poorly soluble in water.Dispersible tablets available.Open capsule and dissolve contents inwater. Bitter taste. (Ref. Pfizer)ACECACBCBuccal tablets and suppositories available.Tablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton- 10 -Updated April 2012Review April 2013

EQUETIAPINEQUININE SULPHATERALTEGRAVIRRAMIPRILRANITIDINEDo not crush slow release preparations.If converting from SR, give the total dailydose in 2 to 3 divided doses.Stop enteral feed half an hour before andafter administration.Stop enteral feed prior to administration.Flush tube before and after.Film-coated tablets are poorly soluble inwater. Manufacturer recommends crushingand mixing in yogurt. (Ref. AstraZeneca)(Ref. MSD Medical Information)Tablets can be crushed. Capsules can beopened and contents dispersed in water.Monitor blood pressure.Effervescent tablets available.BERIFABUTIN1. C2. BBRIFAMPICINCContents of capsule can be emptied insmall amount of water and flavoured.Do not open capsules. Risk of contactsensitization.Use liquid form of each componentseparately (rifampicin, isoniazid andpyrazinamide).Rifater and Rifanah sachets can beimported via BR Pharma.Tablets can be crushed and given in aspoonful of sugar, food puree or yogurt.Crushed tablets can have an anaestheticeffect on the tongue.Orodispersible tablets available.RIFATER / SIMVASTATINSODIUM BICARBONATEABCDECBDo not crush slow release tablets.Oral lyophilisates available for buccaladministration.CBCBBEPoorly soluble in water. Take immediatelyafter crushing, maybe better in yogurt.Has an anaesthetic effect on the tongue.1. B2. EBCapsules can be opened and contentsmixed with water.Ref. Focus Pharmaceuticals LtdTablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton- 11 -Updated April 2012Review April 2013

SODIUM VALPROATESOLIFENACINSOTALOLSPIRONOLACTONESTALEVO 1.2.A1.2.1.2.3.BCBRef. Astellas PharmaBECBESUCRALFATE1. C2. ASULFASALAZINE1.2.1.2.1.2.SULPIRIDETAMOXIFENDo not crush slow release tablets. Monitorplasma levels.Tastes bitter and forms an orange dyewhich may stain. Can be mixed withorange, apple or tomato juice, honey, jamor yoghurt. (Ref. Orion Pharma)Stop enteral feed at least 1h prior toadministration and for 1h after. Flush tubebefore and after.Do not crush enteric-coated or slowrelease tabletsCBCBCBWear a mask if crushing tablets.TAMSULOSIN MRTELMISARTANTEMAZEPAMCapsules can be opened and modifiedrelease granules mixed with water (notcrushed). The mixture should be givenimmediately.B1. C2. BSchedule 3 controlled NETIZANIDINETOLBUTAMIDE1. B2. EBBTOLTERODINETOPIRAMATEABTRAMADOLAABCDECapsules can be opened and contentsmixed with 30g apple sauce or apple juice.Appropriate precautions against toxic dustare recommended: wearing gloves andmask. (Ref. Schering Plough Ltd)Tablets can be crushed and mixed in waterTo convert to liquid, divide the total dailydose by 3 and administer TDS.Stop enteral feed at least 1h prior toadministration and for 2h after. Flush tubebefore and after. Monitor levels.Tablets do not mix well with water whencrushed.Tablets do not disperse readily in water asthey are film-coated, but will disintegrate ifshaken in 10ml of water for 5 minutes.“Sprinkle capsules” can be opened andcontents mixed with soft food.Sachets, soluble and orodispersible tabletsavailable. Capsules can be opened.Tablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton- 12 -Updated April 2012Review April 2013

TRANDOLAPRILTRANEXAMIC HOLIC ACIDOpen capsules and disperse contents inwater. Consider changing to lisinopril liquid.1.2.3.CC1.2.1.2.BEDCapsules can be opened.Capsules can be opened.rdAvoid crushing – risk of 3 party exposureto the powder.CBBCVALPROATE SEMISODIUMGastro-resistant tablets should not becrushed. If half tablet dose needed, takeafter food to minimise GI adverse effects.Open capsules and disperse contents inwater. Monitor blood pressure.VALSARTANVANCOMYCIN1. D2. EBVENLAFAXINEVERAPAMILVIGABATRINVITAMIN B COMPOUNDVITAMIN EWARFARINZINCZOPICLONE1.2.3.4.ABC1.2.Tablets are water-soluble.MR capsules can be opened and sprinkledonto soft food.Do not crush slow release preparations.If changing form a slow releasepreparation, divide the dose into 3 equaldaily doses.Sachets available.CBDEBEStop enteral feed at least 2h prior toadministration and for 2h after. Flush tubebefore and after. Monitor INR closely.Effervescent tablets available.Crushed tablets have bitter taste. Tabletsdissolve in acidic fruit juices (orange).ABRef. GenericsKEY TO DRUG ADMINISTRATION GUIDELINESPlease follow the guidelines in order, as shown in the chart (i.e. number 1 is the first choice ofwhich form to administer the drug in).ABCDETablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non SterilePreparative Services (PSU at Colchester General Hospital).ABCDETablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton- 13 -Updated April 2012Review April 2013

References1. R. White, Handbook of Drug Administration via Enteral feeding Tubes, online, April2012.2. The NEWT Guidelines for administration of medication to patients with enteralndfeeding tubes or swallowing difficulties, 2 ed., May 2010.nd3. The Royal Hospitals. Administering medicines Through Enteral Feeding Tubes, 2ed.4. Medicines for Children, 2003.th5. Guy’s and St Thomas’, Paediatric Formulary, 8 ed.6. Non-Sterile Preparative Services. Extemporaneous products prepared by Prep.Services, March 2011.Prepared April 2012 Medicines Information, Pharmacy Department, Colchester Hospital Foundation University NHS Trust,2012. All rights reserved. Not to be reproduced in whole or in part without the permission of the copyright owner.ABCDETablet will disperse in 1-2 minutes.Tablet will disperse in greater than 2 minutes.Liquid preparation available.Dilute reconstituted injection with 30-60ml of water before administering.Oral solution/suspension can be prepared by local pharmacy or Non Sterile Preparative Services (PSU atColchester General Hospital).Created by Colchester Medicines InformationAuthor: Marie Clifton- 14 -Updated April 2012Review April 2013

EPLERENONE Tablets can be crushed and mixed in apple sauce. (Ref. Pfizer) ERYTHROMYCIN C Erythromycin ethylsuccinate is the only liquid preparation available. When switching from erythromycin stearate tablets, the dose has to be doubled. ESCITALOPRAM B Tablets can be crushed and

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