TM CTO Device MasTeR The CRO Ss - Boston Scientific

Crossing Every LesionPeripheral Vascular InterventionsOffRoadTMRe-entry Catheter SystemTruePathMasterC ro s sTheCTO DeviceTMRubiconTMSupport Catheters0.035“ 0.018“ 0.014“*VictoryTMGuidewiresTip Loads 12 18 25 30 grams*0.035“ 0.89 mm 0.018“ 0.46 mm 0.014“ 0.36 mmV-14 & V-18TMTMControlWire GuidewiresTip Loads V-14 3 6 gramsV-18 6 8 grams

TroubleshootingWire fails to select side branch Steerability Increase wire torque response Add a torque device Add a torquable diagnostic catheter Push Increase Wire Rail SupportFriction-Tip enters lesion but wire fails to follow Wire body curves and bucklesand or Increase Lubricity Increase Catheter lubricityFriction Increase Lubricity Decrease DiameterPush Increase Wire Rail Support Increase Wire Support by adding a Support CatheterTip fails to enter lesion – Wire tip bucklesagainst lesion orPenetrating power Increase Tip Load Decrease Wire Tip Diameter Focus tip force by adding a support CatheterExchange for a Crossing Device Mechanically breakthrough the lesionWire enters Subintimal space but fails to re entertrue lumenChange Support to the wire tipandChange catheter shape will provide backup supportTry different wire typesSmaller wires, stiffer tips, different torque controlorUse a Re entry deviceTo provide direction and to puncture back into the true lumenallowing wire to re enterWire Crosses but device fails to crossand or Profile Smaller Wire Platform Lower profile devicesSupport Increase Wire Rail Support Increase Wire Support by adding a Guiding CatheterWire Prolapses on entry or Flips out onDevice DeliveryChange the Taper Length For NavigationIncrease Taper length, longer tapers allow the wire to follow the tipminimising prolapse For Device DeliveryDecrease Taper length, shorter tapers supports the device closer tothe tip of the wire minimising “flip out” particularly in areas of shortdistal wire purchase

Table of Contents0.035”(0.89 mm) /-GuidewiresPTFE-Coated Starter Guidewire . 6Magic Torque Glidex Coated Hydrophilic Guidewire . 7ZIPWire Hydrophilic Guidewire . 8Back-up Meier Steerable Guidewire . 9Amplatz Super Stiff Guidewire . 9Platinum Plus Guidewire ST . 9TMTMTMTMTMTM0 . 0 18 ”(0.46 mm)GuidewiresThruway Peripheral Guidewire . 10V-18 ControlWire Guidewire with ICE Hydrophilic Coating . 10Victory Guidewire . 11ZIPWire Hydrophilic Guidewire. 11Platinum Plus Guidewire . 11TMTMTMTMTMTM0 . 0 14”(0.36 mm)GuidewiresJourney Peripheral Guidewire . 12Thruway Peripheral Guidewire . 12V-14 ControlWire Guidewire with ICE Hydrophilic Coating . 13Victory Guidewire. 13Platinum Plus Guidewire with Glidex Hydrophilic Coating . 13TMTMTMTMTMTMSuppor t CathetersRubiconTMSupport Catheters . 14CTO DevicesTruePath CTO Device . 16OffRoad Re-entry Catheter System. 17TMTM

Low40/80/100/125/150/180/260SpringCoil NavigatingMagic Torque ModerateHigh180260SpringCoil *CrossingZIPWire Standard and Stiff 1,2ModerateHigh80150180260Nitinol ExtraSupportLow75145180260SpringCoil SuperLow185300SpringCoilDeliverySupportBack-up Meier NavigatingCrossingDeliverySupport(0.46 mm)J J Moderate access wire for catheter placement andexchange Hydrophilic guidewire for access and crossing Extra stiff access wire for strength and stabilityduring catheter placement and exchange, ideal forcontralateral access and carotid proceduresJC Super stiff access wire for strength and stabilityplacing large devices such as thoracic sheaths,and AAA proceduresJ GuidewiresExtraSupportModerate130190300SpringCoil V-18 ControlWire 26 (long taper)8 (short taper)ModerateHigh110150200300PolymerSleeve *ZIPWire Small Vessel 1,28ModerateHigh150180Nitinol Victory 18112182530ModerateHigh195300PolymerSleeve * 4 (short taper)5 (long taper)ExtraSupportModerate145180260SpringCoil (0.36 mm)Standard diagnostic and access guidewireavailable in Fixed Core, Moveable Core, Bentson,Newton and Rosen 2 (short taper)4 (long taper)0.014“ JThruway 1Platinum Plus Descriptions /- GuidewiresAmplatzSuper Stiff 0.018“PTFEModerate(0.89 mm)HydrophillicStarter 10.035“Tip StyleDistalCoatingCoreAtraumaticLubricityGuidewire NameAccessWireLength(cm)RailSupportAngledTip Load(grams)StraightTip ShapeDelivery Support GuidewiresDesigned to provide additional supportfor delivery of large devices and mayaid in vessel straighteningSiliconeCrossing GuidewiresDesigned to provide increasing tip stiffness and excellent torqueresponse to successfully cross lesionsStainless SteelNavigating GuidewiresDesigned to be flexible, steerableand navigate tortuous anatomyNitinolAccess GuidewiresDesigned to be flexible, have a softatraumatic tip, and provide enoughsupport to deliver diagnostic devices Access and crossing lesions within acutely angledvessels, such as Renal arteries Crossing stenosed lesions / ideal for step-upstrategy combined with higher gram load wires Hydrophilic guidewire for access and crossing Dedicated guidewires for Intraluminal techniqueto cross calcified lesions or tight plaque or chronictotal occlusions Crossing stenosed lesions / extra support fordevice deliveryGuidewiresJourney 1.3LightHigh185300Micro-cutNitinolSleeve *Thruway 11.3 (short taper)1.4 (extra long taper)1.7 (long taper)ExtraSupportModerate130190300SpringCoil ExtraSupportHigh182300PolymerSleeve * **Navigating highly tortuous, distal anddifficult-to-access anatomy NavigatingV-14 ControlWire 2CrossingDeliverySupport6 (short taper)3 (long taper)ModerateJ Access and crossing lesions within acutely angledvessels, such as Renal arteries Crossing stenosed lesions / ideal for step-upstrategy combined with higher gram load wiresVictory 14112182530ModerateHigh195300PolymerSleeve * Dedicated guidewires for Intraluminal techniqueto cross calcified lesions or tight plaque or chronictotal occlusionsPlatinum Plus 7ExtraSupportModerate180300SpringCoil Crossing stenosed lesions /extra support for devicedelivery

PTFE-coated StarterTMGuidewire – Fixed Core1 4(0.89 mm) /-Accessb For selective catheterization and all diagnostic and interventional proceduresUPN –Catalog NumberDiameter(in)(mm)Length(cm)Tip raightLength(cm)Tip Taper(cm)TipShape3 mm JDiameter:(in)(mm)0.035 0.890.038 0.97(0.46 mm)0.018M0014920110. 018”M001492001Diameter:(in)(mm)0.018 0.460.025 0.640.028 0.710.032 0.810.035 0.890.038 0.970.035” ((0.0 . 8899 mmm )m /) - / 0. 035”Guidewires 0.035”J-Curved Fixed Core 50113 mm JM0014911510.0350.8915041.5 mm JM0014922210.0350.894083 mm JM0014923010.0350.8980103 mm JM0014922310.0350.8910083 mm JM0014911710.0350.89125103 mm JM0014911810.0350.89150103 mm JM001491201c0.0350.89180103 mm JM001491211c0.0350.89260103 mm JM0014922510.0350.8915096 mm JM001492261c0.0350.8918096 mm JM0014922710.0350.89150812 mm JM0014911910.0380.97150113 mm JM0014922810.0380.97150812 mm JTMGuidewire – NewtonAccessa For access in tortuous and highly diseased vessels and smoothadvancement during peripheral interventions*bUPN –Catalog NumberDiameter(in)(mm)Length(cm)Tip 0014915110.0350.8915015StraightPTFE-coated StarterTMGuidewire – New BentsonDiameter:(in)(mm)0.035 0.89S u ppo r t C at he t e r sPTFE-coated Starter( 0 .36 m m )M0014911610. 014”UPN –Catalog NumberAccess bUPN –Catalog NumberDiameter(in)(mm)Length(cm)Tip M001491471c0.0350.8918015Straight* Data on file at Boston Scientific.a Packaged 10/boxb Packaged 10/box for lengths up to 150 cm included.c Packaged 5/box for lengths up to 150 cm included.d Packaged 3/boxDiameter:(in)(mm)0.035 0.89CTO Devices For smooth advancement during peripheral intervention and forall extremely delicate diagnostic and interventional procedures*

2 4(0.89 mm) /-PTFE-coated StarterAccessTMGuidewire – Heavy Duty Fixed Core aUPN –Catalog NumberM001492501Diameter(in)(mm)0.035Length(cm)Tip Taper(cm)TipShape1503Straight0.89PTFEcoated StarterAccessTMGuidewire – Moveable Core0.035” ((0.0 . 8899 mmm )m /) - / 0. 035”Guidewires 0.035” Offering varying tip flexibility for tortuous vessels and all diagnostic and interventional proceduresDiameter(in)(mm)Length(cm)Tip .0380.971500StraightLength(cm)Tip Taper(cm)TipShapeUPN – 5001.5 mm JbM0014913210.0350.8915003 mm JM001491351b0.0350.8915006 mm JbM0014913410.0350.8926003 mm JM001491331b0.0380.9715003 mm JPTFE-coated StarterTMGuidewire – Double EndedDiameter(in)(mm)AccessaLength(cm)Tip Taper(cm)TipShapeM0014922010.0350.8915041.5 mm JM0014922410.0350.8915043 mm JTMGuidewire – Rosen Heavy Duty a( 0 .36 m m )PTFE-coated Starter0. 014”UPN –Catalog NumberDiameter:(in)(mm)0.035 0.890.038 0.97(0.46 mm)M001491101a0. 018”UPN –Catalog NumberAccess For additional support during procedures in highly diseased vessels,renal procedures and interventions in anatomy with short distal purchaseUPN –Catalog NumberM001491551Diameter(in)(mm)0.0350.89TMTip Taper(cm)TipShape15041.5 mm JDiameter:(in)(mm)0.035 0.89S u ppo r t C at he t e r sMagic TorqueLength(cm)NavigatingGlidex Coated Hydrophilic Guidewire d Glidex hydrophilic coating on 10 cm distal tip 3 cm shapeable distal tip Navigating wire indicated for catheter placement and exchange.UPN –Catalog NumberDiameter(in)(mm)Length(cm)Tip .0350.892605Straight* 4 distal platinum Magic markers spaced at 1 cm incrementLength (cm): 180, 260Tip Shape:ShapeableCTO DevicesM001465911Diameter:(in)(mm)0.035 0.89

ZIPWireTM3 4(0.89 mm) /-CrossingHydrophilic Guidewire Secure control when sub-selecting distal and angulated branch vessels Excellent visibility for accurate positioningUPN –Catalog NumberDiameter(in)(mm)Length(cm)Tip ngledLength(cm)Tip Taper(cm)TipShapeDiameter:(in)(mm)0.018 0.460.025 0.64Standard shaft cUPN –Catalog edM00146165B10.0380.971503StraightLength(cm)Tip Taper(cm)TipShapeAngledTip Shape:AngledStraightStiff shaft cUPN –Catalog d Long Taper cUPN –Catalog m)Tip Taper(cm)TipShape1508AngledLength(cm)Tip Taper(cm)TipShapeDiameter:(in)(mm)0.035 0.890.038 0.97Stiff Long Taper cUPN –Catalog 71505AngledLength(cm)Tip Taper(cm)TipShape15033 mm JDiameter:(in)(mm)0.035 0.890.038 0.97Length (cm): 80, 150, 180, 260Length (cm): 150Tip Shape:AngledStraightTip Shape:AngledLength (cm): 150, 260Tip Shape:StraightSupport CathetersM00146300B1Diameter:(in)(mm)0.035 0.890.038 0.97(0.36 mm)0.035Length (cm): 150, 180, 2600.014”M00146151B1Diameter:(in)(mm)0.035 0.890.038 0.97(0.46 mm)0.0250.018”M00146125B1 Excellent kink-resistance Indicated for enhance steerability and control for maneuveringthrough difficult anatomy0 . 00 3. 053 5”” ((00 .8899mmm )m /) - / -Guidewires 0.035”J-Tip cM00146350B1Diameter(in)(mm)0.0350.89a Packaged 5/box for lengths up to 150 cm included.CTO DevicesUPN –Catalog Number