BME 7730 / ECE 7740 Medical Imaging Systems

BME 7730 / ECE 7740 – Medical Imaging SystemsFall ---------------------General informationCourse TitleMedical Imaging SystemsCourse numberBME 7730 / ECE 7740Course referencenumberCredit hours16455 (BME) – 16760 (ECE)Lecture TimeMW – 6:30 – 7:45 PMRoomMANO 0225InstructorOfficeMohammad Mehrmohammadi, PhDAssistant ProfessorBioengineering, #2118Phone313-577-8883E-mailmehr@wayne.eduTeaching AssistantTBDTentative Office Hours:Instructor: W 5-6 PM and F 9-10 AM (or by appointment)TA: TBD3COURSE DESCRIPTION:This course serves as a general introduction to medical imaging technologies. The main objectiveof this course is to expose students to the world of medical and biomedical imaging with emphasison principles, approaches and applications of major modern imaging modalities: X-rayradiography and computed tomography (CT), magnetic resonance imaging (MRI), nuclearmedicine (single photon emission computed tomography (SPECT), and positron emissiontomography (PET)), and ultrasound imaging (including ultrasound tissue elastography andphotoacoustic). For each imaging modality, the following topics will be covered: 1) physicalprinciples (basic physics); 2) a model describing how imaging signals are being generated; 3)imaging system hardware; 4) image reconstruction/formation; 5) noise (sources) artifacts; 6)research and clinical applications.After an introduction to biomedical imaging and introducing major imaging modalities, we willcover X-ray imaging and Nuclear Medicine including computed tomography (CT), single photonemission computed tomography (SPECT), and positron emission tomography (PET). Then, wewill focus on nuclear magnetic resonance covering magnetic resonance imaging (MRI) and MRspectroscopy. Finally, ultrasound (and Photoacoustic) imaging will be introduced and discussed.A very short overview on optical imaging modalities will also be given to the students.Overall, fundamental similarities between the imaging equations of the different modalities willbe stressed, and vital differences between different modalities will be discussed.

BME 7730 / ECE 7740 – Medical Imaging SystemsFall ---------------------Topics will be covered:1. Introduction to medical imaging2. Projection radiography3. Computed tomography (CT) or Computer aided tomography (CAT)4. Nuclear Medicine: planar imaging, SPECT and PET5. Nuclear magnetic resonance imaging (a.k.a. MRI)6. Ultrasound imaging (grayscale, Doppler ultrasound, Ultrasound-based modalities such asUltrasound elastography and Photoacoustic)7. Optical imaging (if time allows! - Very brief overview - confocal imaging, fluorescentimaging, and tentatively optical coherence tomography- OCT)9. Review and comparison of biomedical imaging modalities, outlook and trend in biomedicalimaging, other emerging imaging modalitiesPre-requisites1: Graduate (MS or PhD) and senior undergraduate students in an engineering or appliedscience degree programs are eligible to register. Medical students couldregister for the class after obtaining permission from the instructor.Basic experience in MATLAB ProgrammingRequired textbook2:Title: Introduction to Biomedical ImagingAuthor: Andrew WebbPublisher: Wiley-IEEE PressYear: 2002ISBN: 0-471-23766-3Supplementary textbooks/material:Title: Imaging Systems for Medical Diagnostics Fundamentals, TechnicalSolutions and Applications for Systems Applying Ionizing Radiation, NuclearMagnetic Resonance and UltrasoundAuthor: Arnulf Oppelt (Editor)Publisher: John Wiley & Sons IncYear: 2006ISBN: 978-3-89578-226-81Contact the instructor if you have not passed these classes to make sure you are eligible for taking BME 7730/ECE7740.2The textbook is available at the bookstore. A copy of the book is also ordered through the library reserve systemand must be available in UGL for temporary use.

BME 7730 / ECE 7740 – Medical Imaging SystemsFall -------------------- Medical Imaging Signals and Systems, Jerry L. Prince and Jonathan LinksISBN: 0130653535, 2005, Prentice HallThe Essential Physics of Medical Imaging (2nd Edition), J.T. Bushberg, J.A. Seibert, E.M. LeidholdtJr., J.M. Boone. ISBN: 0683301187, hardcover, 934 pages, December, 2001Practical Experiences/participation: CT: A tour clinical CT facility.Nuclear medicine: A tour clinical PET/SPECT facility.Ultrasound: Both observation and practical experiment with an Ultrasound ScannerMRI: A tour clinical MRI facility.Course objectivesThe main objective of this course is to introduce students to major biomedical imaging modalities,concentrating on X-ray radiography, computed tomography (CT), nuclear medicine (SPECT andPET), magnetic resonance imaging (MRI), and ultrasound. Optical imaging will be very brieflycovered. The approach used evolves from basic physical principles to image formation, imagereconstruction, and hardware design to clinical applications.Learning objectivesUpon successfully completion of the course, the student will gain: Concepts of image quality, signal and noise, image processing, and image Basic knowledge of Have a basic knowledge of medical imaging systems, namely diagnosticultrasound, X-ray imaging, computed tomography, nuclear magnetic resonance imaging, andpositron emission tomography in terms of physics, instrumentation, signal/image processing,and applications Knowledge of fundamental interactions between different forms of energy and biologicaltissues Basic and practical knowledge of relevant signal and image processing techniques formedical image reconstruction and processing Mathematical foundations and the computer algorithms that are used in image formation andimage reconstruction (Use an engineering programming language, MATLAB, to performbasic image simulation and image reconstruction) Clear vision of clinical imaging facilities in practice through facility visits Knowledge of current clinical applications of each imaging modality Knowledge of and understand advantages and limitations of imaging modalities An ability to apply knowledge of mathematics, science, and engineering to fully understandthe general meaning and applications of biomedical imaging systems. An ability to function on multidisciplinary teams An ability to identify, formulate, and solve engineering problems An ability to communicate effectively and professional presentation A knowledge of contemporary issues in the field of medical diagnostic

BME 7730 / ECE 7740 – Medical Imaging SystemsFall ---------------------Specific outcomes of the course1. Understanding the physics of radiography2. Understanding radiography system3. Understanding X-ray computed tomography (CT) system4. Understanding the physics of ultrasound5. Understanding ultrasound imaging system.6. Understanding the physics of radionuclide imaging.7. Understanding emission computed tomography system, including PET and SPECT.9. Understanding the physics of magnetic resonance.10. Understanding magnetic resonance imaging system11. Design image reconstruction algorithms12. Use MATLAB to perform medical image reconstruction and analysisGrading: Your final grade will be based on quizzes, homework, final project, group presentation, andexams as follows. The final grade is determined from total points. The points are estimated to be:Homework10%Computer Assignments15% (3 assignments - 5% each)Quizzes10%ExamsExam 1: 25%Exam 2: 25%Final research project15 %

BME 7730 / ECE 7740 – Medical Imaging SystemsFall ---------------------Tentative ScheduleWeek #DateBookChapterSubjectHomework/computer assignmentClasses begin on 08/30/2017108/30/201709/04/2017Course introduction,Introduction to Biomedical Imaging /OverviewNANo class – Holiday (Labor Day)209/06/2017Review: Medical Imaging Basic Mathand Concepts509/11/2017Review: Medical Imaging Basic Mathand Concepts509/13/2017Review: Medical Imaging Basic Mathand Concepts509/18/2017X-ray imaging: Introduction andPhysics of X-ray tissue interaction andintroduction to radiography109/20/2017Projection Radiography (Hardware)109/25/2017Projection Radiography, X-raycomputed Tomography1Final Project Topic Selection09/27/2017X-ray computed Tomography (Imagereconstruction)1Computer Assignment #110/02/2017X-ray computed Tomography (Imagereconstruction)110/04/2017General Principles of NuclearMedicine/Radioactivity2Recorded class (movie) / Self study34Final Project introduction5610/09/2017710/11/2017The Production of Radionuclides/Typesof Radioactive Decay/Instrumentation: Gamma CameraSingle Photon Emission ComputedTomography (SPECT) / PositronEmission Tomography (PET)/ Imageformation2Final Project Abstract and SpecificAims (1 page)2Computer Assignment #1 Due

BME 7730 / ECE 7740 – Medical Imaging SystemsFall ---------------------10/16/20178Exam 1 (Basics of Imaging, Radiography, X-Ray, and Nuclear Medicine)10/18/2017Magnetic Resonance Imaging:Introduction and Overview410/23/2017Physics of MRI / Nuclear Magnetism410/25/2017Bloch equations / MR imagingsequence4MR Imaging 1Applications of MR imaging and recentadvancements in MRI (including fMRIand MR molecular imaging)Principles of Ultrasonic Imaging /Acoustic wave propagation / AcousticImpedanceFinal Project Progress report (2 pages)Computer Assignment #243Tentative: Visit a MR facilityComputer Assignment #2 Due11/08/2017Pulse-echo Ultrasound Imageformation (beamforming)311/13/2017Ultrasound Instrumentation311/15/2017Doppler Ultrasound / UltrasoundContrast Agents, Harmonic Imaging,Pulse Inversion Technique311/20/2017Ultrasound Elasticity Imaging /Photoacoustic Imaging3 Notes12Visit to DMC PET/CT FacilityComputer Assignment /06/2017No class – Holiday (Thanksgiving)Safety and Bioeffects in UltrasonicImaging/Clinical Applications ofUltrasoundShort overview of Optical ImagingModalities3NAUltrasound and Photoacoustic ImagingLab visit – (Hands on experiment withprogrammable Ultrasound Machine)NAComputer Assignment #3 DueFinal project presentationsConclusion: Comparison betweenimaging modalities and theirapplications

BME 7730 / ECE 7740 – Medical Imaging SystemsFall ---------------------Recent advancements in medicalimaging: Multi-modal and hybridimaging modalitiesQA and preparation for Final Exam12/12/2017Study Day – No class/exam12/14/2017Final exam (MRI, Ultrasound Imaging)16

BME 7730 / ECE 7740 – Medical Imaging Systems . The Essential Physics of Medical Imaging (2nd Edition), J.T. Bushberg, J.A. Seibert, E.M. Leidholdt . Understanding the physics of radionuclide imaging. 7. Understanding emission computed tomography system, including PET and SPECT. .