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Mental healthDan I LubmanKate HallAmy PennaySathya RaoManaging borderlinepersonality disorderand substance useAn integrated approachBackgroundAlthough substance use is a common feature of borderlinepersonality disorder, regular use is associated with greaterlevels of psychosocial impairment, psychopathology, selfharm and suicidal behaviour and leads to poorer treatmentoutcomes. Management of co-occurring substance usedisorder and borderline personality disorder within primarycare is further compounded by negative attitudes andpractices in responding to people with these conditions,which can lead to a fractured patient-doctor relationship.ObjectiveThis article provides an overview of how the generalpractitioner can provide effective support for patients withco-occurring borderline personality disorder and substanceuse disorder, including approaches to assessment andtreatment, the therapeutic relationship, referral pathwaysand managing risk and chronic suicidality.DiscussionDespite the complexities associated with this population,GPs are ideally placed to engage patients with co-occurringborderline personality disorder and substance use disorderin a long term therapeutic relationship, while also ensuringtimely referral to other key services and health professionals.To provide the most effective responses to this patient group,GPs need to understand borderline personality disorder andits relationship to substance use, develop an ‘explanatoryframework’ for challenging behaviours, implement mechanismsfor reflective practice to manage negative countertransference,as well as learn skills to respond adequately to behaviourswhich jeopardise treatment retention.Keywords: borderline personality disorder; substance use;drugs; alcohol; treatment376 Reprinted from Australian Family Physician Vol. 40, No. 6, JUNE 2011While population surveys reveal that around 1–2% ofthe general population meet the criteria for borderlinepersonality disorder (BPD),1 the prevalence of BPD withinprimary care is about fourfold higher, although many ofthese patients are not recognised as having an ongoingmental health problem by their general practiitoner.2Alcohol and drug use is common among this population,with between 21–81% reporting a co-occurring substanceuse disorder (SUD), and up to 65% of substance usersin treatment meeting the criteria for BPD.3 Such figuresare concerning, as patients with co-occurring SUDand BPD present considerable challenges for bothprimary care and drug treatment services, given theirassociation with greater levels of psychosocial impairment,psychopathology, substance use, unsafe injecting, selfharm and suicidal behaviour.4,5 Treatment studies alsohighlight that patients with co-occurring SUD and BPDhave higher rates of relapse, treatment noncompliance andpoorer outcomes than those with either diagnosis alone,6while SUD significantly reduces the likelihood of clinicalremission of BPD.7Complexities inherent in the treatment of co-occurring SUD andBPD are further compounded by negative attitudes and practices onthe part of health professionals in responding to people with theseconditions. This is especially evident in the context of substanceuse, where undiagnosed BPD may underlie a difficult patient-doctorrelationship and delay access to appropriate treatment. Althoughstigma associated with this patient group is high,8 such attitudesmost likely reflect a lack of skills and knowledge in relation tothe specific needs of this population, as well as the negativecountertransference commonly experienced in working with thesepatients.9 Indeed, it has been suggested that individuals with BPDconstitute the ‘most psychologically challenging patients a primarycare physician ever encounters’, and this is especially true whensubstance use is also prominent.10

Despite the complexities of this population, GPs are ideally placedto engage patients with BPD and SUD in a long term therapeuticrelationship characterised by warmth, containment and hope,while also ensuring timely referral to other key services and healthprofessionals. In order to provide effective support for this population,it is important that practitioners understand BPD and its relationshipto substance use, and develop an ‘explanatory framework’ forchallenging behaviours, mechanisms for reflective practice to managecountertransference, as well as skills to respond adequately tobehaviours which jeopardise treatment retention.Why do BPD and SUD commonlyco-occur?Many of the core features of BPD are also independent risk factorsfor the development of SUD, and it is therefore not surprising thatthese conditions commonly co-occur. For example, both impulsivityand affective dysregulation have recently been identified as keyvulnerability factors in the development and maintenance of addictivedisorders.11 In addition, while the interaction between childhoodtrauma and poor attachment are frequently implicated in the aetiologyof BPD,9 clinical studies identify high rates of trauma (and associatedpost-traumatic stress disorder) among patients with SUD presentingto treatment services.12,13 Such high rates of trauma may explain thehigh rates of BPD among patients with SUD within treatment settings,and the heavier patterns of substance use among those with SUD whohave experienced trauma, particularly when faced with stressful ornegative emotional situations.13Management in primary careAssessment and diagnosisPatients with co-occurring BPD and SUD are highly likely to attendprimary care, although the form of presentation is unlikely to bestraightforward. Given the high rates of comorbidity with other mentaldisorders, patients may initially present with: symptoms of depression or anxiety suicidal ideation physical complications of their substance use, or difficulties in their relationship or workplace.Early identification is preferable, given the many costs associated withdelays in diagnosis, and it is therefore important that practitioners arefamiliar with the clinical characteristics (Table 1) as well as the risk ofassociated negative countertransference (see below).Giving a patient a diagnosis of BPD can be both a liberating (thepatient has a clearer understanding of themselves and how thingscan change) and at times damaging (the patient is stigmatised byservice providers and excluded from treatment) experience. However,despite such stigma, appropriate diagnosis can enable accuratepsychoeducation, guide appropriate treatment and avoid damagingtreatment responses such as inappropriate prescribing and extendedinpatient admissions. Nevertheless, it can be challenging to make aTable 1. Clinical characteristics that can helpidentify a person suffering from borderlinepersonality disorderMultiple self injurious acts (eg. cutting, burning,overdosing), recurrent suicidal attempts, gestures andthreatsChronic suicidal ideationPoor self concept or self image – often these patientsdislike themselves intensely and some may have bodyimage issuesStormy interpersonal relationships, intolerance tolonelinessEmotions: dysregulated, hyper-reactive, anger outbursts,anxiety and chronic dysphoriaOften attracts dysfunctional relationshipsHistory of sexual abuse, neglect, invalidatingbackgroundsFear of rejection/abandonmentExperience numerous crises and have chaotic lifestyleTransient, stress related paranoid ideation and/ordissociative episodesMarked impulsivity (eg. excessive spending, engagingin unsafe sex, substance abuse, reckless driving, bingeeating)definitive diagnosis of BPD in the context of SUD as many commonfeatures of BPD (eg. impulsivity, dysphoria, emotional lability, selfdestructive behaviours, poor interpersonal relationships, poor senseof self) are also prominent in patients with SUD. In addition, regular,heavy substance use can lead to marked changes in a person’s affect,personality and behaviour, particularly if they have a chaotic patternof using, regularly consume both stimulants and depressants, and/oroscillate between periods of intoxication and withdrawal.Diagnosis should include gaining collateral information and alongitudinal perspective (preferably following a period of abstinence).Providing psychoeducation to patients and family members about thediagnosis and the interaction between BPD and SUD is particularlyimportant. The therapeutic relationship is likely to be more effective ifthere is a shared understanding between patient and practitioner aboutthe aetiology of both disorders, including a biological and psychosocialformulation of their development, and how any challenging behavioursand internal experiences are triggered and maintained.Building a therapeutic relationshipA positive therapeutic relationship plays a central role in themanagement of both BPD and SUD. In psychotherapies for this disorder,the therapist provides a relationship that helps identify and breakthe self defeating interpersonal patterns characteristic of previousrelationships.14 Giving the patient every opportunity to identify andchange their maladaptive interpersonal patterns and learn newinterpersonal skills to form healthy relationships constitute an importantReprinted from Australian Family Physician Vol. 40, No. 6, JUNE 2011 377

FOCUS Managing borderline personality disorder and substance use – an integrated approachpart of any treatment. In this regard, clinicians should seize every singleinterpersonal opportunity to build up the skill level of this patient group.Issues in the therapeutic relationship are best anticipated andaddressed up front before behaviours that interfere with treatment(eg. frequent nonattendance, repeated crisis presentations) orinterpersonal difficulties damage treatment retention or progress.A key aspect of the GP’s role is to embody the potential for changeand hope, while anticipating and responding to difficulties with thetherapeutic relationship. In this context, it is important to recognisethat change is likely to be slow and preventing serious harm can be animportant focus of treatment. However, finding the balance betweenempathic validation and working toward behaviour change is incrediblychallenging. Responding flexibly and moving along this continuum,while maintaining boundaries and responding to risk of harm, isessential in maintaining an effective therapeutic alliance, which gentlybut persistently moves the patient toward change. Key principlesin the response to patients with chronic interpersonal difficultiesare discussed by many therapy styles. The main characteristics thatembody the ideal style of therapeutic relationship include:15 empathy compassion curiosity collaboration respect openness connection, and authenticity on the part of the treating practitioner.Recognising negative countertransferenceNegative countertransference (the unconscious development ofnegative feelings toward the patient on the part of the clinician)is common when working with patients with BPD – and in factshould be expected – particularly when complicated by SUD.Working successfully with patients with BPD and co-occurring SUDrequires many layers of support in order to prevent any negativecountertransference adversely impacting treatment planning or theresponse to crisis presentations.Practical strategies that GPs can readily implement include: clinical or collegial supervision to discuss negativecountertransference responsibility of client management lying with a team of serviceproviders and not individual practitioners external secondary consultation when treatment is not progressing appropriate practice policies and procedures to manage difficultbehaviours in the waiting room, and support from your practice colleagues to review treatment planning,help identify blind spots, offer alternatives, validate your efforts,and hold hope for change.Clinicians should also be aware of the potential for romanticcountertransference and should seek advice and assistance from asenior colleague or a psychiatrist in the first instance.378 Reprinted from Australian Family Physician Vol. 40, No. 6, JUNE 2011Staying focused on the underlying needsof the patientOvercoming frustration and avoiding reacting with a rejecting orjudgmental response is difficult, but can be achieved by maintainingfocus on the underlying needs of the patient. To this end, GPs shoulddevelop an explanatory framework for why people with BPD and SUDappear to self sabotage treatment, purposely damage the therapeuticrelationship and have difficulty with motivation. Ongoing self reflectionis essential in maintaining this framework. The practitioner’s rolein helping the patient to develop less destructive ways of relatingto others and assissting them in accessing treatment is critical. Inthis regard, it is important that GPs have an understanding of theunderlying experience of BPD co-occurring with SUD. The ongoing anddaily difficulties as described in Table 1 make engaging appropriatelyin a therapeutic relationship extremely difficult. An overly reactiveemotional system, combined with an inability to regulate theseextreme emotional experiences, is central to the underlying experienceof BPD. This dysregulation of emotion is often experienced bypatients with BPD as intense highs and lows that feel intolerableand unrelenting, with substance abuse being a key coping strategy.Recommendations for the treatment of patients with BPD and SUD arelisted in Table 2.Table 2. Recommendations for treatment ofpatients with BPD and SUD within the primarycare setting2Ensure early detection and referral to mental healthservice or psychiatrist for psychotherapyAddress the co-occurring SUD, including relevantpharmacotherapy or referral to specialist drug treatmentActively treat any co-occurring mental disorders (eg.major depression)Educate patient and family about the diagnosisShow interest and concern in the patient whilemaintaining clear boundariesAcknowledge the patient’s feelings, but be clear that youwill only tolerate appropriate behaviour at the practiceDefuse any potential confrontations by remaining calmand neutralPrescribe wisely (eg. frequent dispensing such asweekly; a single identified pharmacy; trials of medicationlinked to clearly defined outcomes; avoid polypharmacy;prescribe opiates and benzodiazepines with caution)Schedule regular structured appointmentsDevelop a crisis management plan with the patientHave a chaperone present when conducting physicalexaminationsEnsure frequent communication between all treatmentproviders to avoid splitting (ie. playing one practitioneragainst another)Engage in clinical supervision or case review with acolleague

Managing borderline personality disorder and substance use – an integrated approach FOCUSTreatment contractingTreatment contracting can be useful with patients who have BPD,especially if done with consideration and reflection. Treatmentcontracting, unlike informed consent, is a negotiation between youand the patient about the expectations of each other during thecourse of treatment, and indicates both you and the patient sharethe responsibility for treatment. Together, you should both identifythe goals, purpose and practical arrangements of treatment (suchas frequency of appointments). Treatment contracts should not beseen as punishment for poor behaviour, but an opportunity to addressmotivation, elicit commitment, as well as establish clear expectationsand boundaries.16Referral for long term psychotherapyGiven the complexity of issues inherent in co-occurring BPD and SUD,referral for longer term psychotherapy with a psychiatristand/or clinical psychologist is an important consideration in treatmentplanning. Indeed, there is good evidence for recovery from manyof the more debilitating aspects of BPD and SUD, such as chronicself harming, with adapted cognitive behaviour therapy (CBT)approaches such as dialectical behaviour therapy (DBT).17,18 Similarly,psychoanalytical therapy adapted for co-occurring BPD and SUD(eg. dynamic deconstructive psychotherapy [DDP]) has been shownto be effective.6 Importantly, studies of co-occurring SUD and BPDhave demonstrated comparable treatment outcomes to SUD alone aslong as patients remain in treatment. However, treatment adherenceis an obvious challenge for patients and significant support andmanagement is usually required to retain patients in treatment onceinitial crises have resolved. Referral to specialist alcohol and drugtreatment for ongoing counselling, detoxification or rehabilitationshould also be considered, while self help groups such as AlcoholicsAnonymous (AA) and Narcotics Anonymous (NA) can provideadditional support.Family members may also require referral for support as the impactof having a family member with co-occurring BPD and SUD cannotbe underestimated. Children of patients with this presentation areparticularly vulnerable. It is therefore advisable that family membersreceive treatment from different practitioners to avoid any potentialconflict of interest or ethical dilemmas.overdosing on medications.21 Patients with BPD and co-occurringSUD often seek medications to address their underlying difficulties.In response, GPs (and other clinicians involved in their care) shouldregularly emphasise the need for nonpharmacological approachesto these problems. Making this explicit in the treatment plan canhelp ensure that discussions regarding medications do not become afocus of future consultations. Pharmacotherapy for alcohol or opiatedependence should be pursued in patients with co-occurring BPDand SUD if appropriate (eg. anticraving agents or opiate substitutionpharmacotherapy).Opioids or benzodiazepines should be prescribed with caution asthey are more likely to result in aberrant use and dependence amongpatients with BPD. If these medications are needed, measures toreduce risk need to be put in place. This includes an agreed planfor ceasing medications before their commencement, prescribingfor limited periods of time, frequent dispensing (eg. weekly), anda single identified pharmacy. Trials of medication, linked to clearlydefined outcomes, should form part of a care plan that is integratedinto the treatment contract. Gourlay et al’s ‘universal precautions’ forprescription medications are particularly relevant in this context.22Indeed, it is important that practitioners do not to unwittinglycontribute to the development or maintenance of SUD in this group ofpatients.A coordinated approachOngoing communication between all treatment providers is essentialfor a coordinated treatment approach and a designated casecoordinator, who is responsible for managing communication betweenprofessionals, is recommended to ensure splitting does not occur.Splitting is a defence mechanism often experienced by BPD patients,and is usually the result of the patient’s efforts to get rid of unbearableinner emotional experiences. This can lead to the patient havingpolarised views about different members of the treating team. In turn,team members may develop polarised views about the patient (ie.being ‘all good’ or ‘all bad’), resulting in conflict over the treatmentapproach. Splits often occur along pre-existing divisions betweentreatment providers, therefore it is essential that splitting is identifiedearly and processed. Regular communication and supervision canassist in resolving and managing splitting effectively.MedicationRisk management and chronic suicidalityWhile psychotropic medications are very commonly prescribed byhealth professionals for patients with BPD, there is limited evidence toguide rational pharmacotherapy and it is best to make a collaborativedecision with the patient around medication.19 There is no currentmedication that is approved for the management of BPD, althoughthere is some evidence that low dose atypical antipsychotics and/or mood stabilisers may be effective in treating core symptoms.Antidepressants should only be prescribed for the treatment ofcomorbid major depression and polypharmacy is best avoided,20particu

Although substance use is a common feature of borderline personality disorder, regular use is associated with greater levels of psychosocial impairment, psychopathology, self harm and suicidal behaviour and leads to poorer treatment outcomes. Management of co-occurring substance use disorder and borderline personality disorder within primary

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