BIOINFORMATICS - Magadhmahilacollege
BIOINFORMATICSStudy Material for :B.Sc. Part IIIBotany Hons.Paper VDr. Pushpanjali KhareSr. Asstt. Professor &Head, Deptt. of BotanyMMC (PU)Patna
INTRODUCTION BIOINFORMATICS is the field of science in which biology, computerscience, statistics applied mathematics and information technologymerge to form a single discipline It is a latest discovery of new biological insight which create a globalperspective from which unifying principles in biology can be discerned Basically it is a management system of creating and restoring theinformation of molecular biology in the form of data, codes, graph andstructure It is a result of HUMAN GENOME PROJECT and creating“GENOMIC REVOLUTION”,
Ref: Biowits* Computer Science includes IT
COMPONENTS OF BIOINFORMATICS1. CREATION OF DATABASES: Involves the organizing, storage and management of the biologicaldata sets Databases are accessible and submit new entries. Protein sequencesdata bank for molecular structures2. DEVELOPMENT OF ALGORITHMS AND STATISTICS: Involves the development of tools and resources to determine therelationship among the members of large data sets Comparison of protein sequence data with the already existingprotein sequences3.ANALYSIS OF DATA INTERPRETATION:Includes DNA, RNA and protein sequences, protein structure, geneexpression profiles and biochemical pathways
AREA OF BIOINFORMATICSRef: Biowits
BIOINFORMATICS TOOLS There are certain sets of programming applicationswhich have been designed and work as tools in thefield of bioinformatics. They are:1. BLASTS2. Fast A3. Emboss4. Clustal W5. Ras Mol
FORMS IN WHICH BIOLOGICAL DATA IS STOREDHOMOLOGYSEARCHESPRIMARY, SECONDARYCOMPOSITE DATABASERef: Biowits
SEQUENCE ANALYSIS It is the process of subjecting a DNA, RNA or peptide sequence to any of awide range of analytical methods to understand its features, function,structure or evolution It includes- Sequencing: Sequence assembly Alignment: Searching ( in Databases) On the basis of number of comparing sequencing strand, it is of two types:Pair wise alignmentMultiple Sequence Alignment
TYPES OF SEQUENCE ALIGNMENT
STRUCTURAL BIOINFORMATICSRef: Biowits
STRUCTURAL BIOINFORMATICS
DATABASE There are various types of data base designedto study and store different molecularinformation. The different databases are:Primary DatabaseSecondary DatabaseComposite Database
PRIMARY DATABASERef: BII
SECONDARY DATABASERef: BII
COMPOSITE DATABASECOMBINES DIFFERENT FORMS OF PRIMARY DATA BASERef: BII
APPLICATION OF BIOINFORMATICS Sequence mapping of biomolecules (DNA,RNA and proteins) Identification of nucleotide sequences of functional gene Finding of sites that can be cut by restriction enzymes Prediction of functional gene products To trace the evolutionary trees of genes For the prediction of 3-dimensional structure of proteins Molecular modelling of biomolecules Designing of drugs for medical treatment Handling of vast biological data which otherwise is not possible Development of models for the functioning of various cells, tissues and organs Designing bioweapons
THANK YOU Students are requested to share their queries onwhatsapp group of class: MMC botany(D2) OR Khare.pushpanjali2@gmail.com OR # 9708063491
STRUCTURAL BIOINFORMATICS Ref: Biowits. STRUCTURAL BIOINFORMATICS. DATABASE There are various types of data base designed to study and store different molecular . Identification of nucleotide sequences of functional gene Finding of sites that can be cut by restriction enzymes Prediction of functional gene products
Bioinformatics Crash Course Ian Misner Ph.D. Bioinformatics Coordinator UMD Bioinformatics Core . Bioinformatics!Core The Plan Monday – Introductions – Linux and Python Hands-on Training Tuesday – NGS Introduction – RNAseq with Sailfish (Dr. Steve Mount, CBCB) – RNAse
SECTION-A: Attempt any five questions. SECTION-B: Attempt any five questions. SECTION–A Short Answer type Questions: (60-80 Words) 5 5 25 Marks 1. What is the role of internet in bioinformatics? 2. How bioinformatics assist in drug designing? 3. Write a short note on Internet Protocol (IP). 4. What is Pattern mining? 5.
volumes of biological information in bioinformatics database. They also provide some bioinformatics tools for database search and data acquire. With the explosion of sequence information available to researchers, the challenge facing bioinformatics and computational biologists is to aid in biomedical researches and to invent efficient toolkits.
tronics, Physics, Statistics, or Business Informatics. 8 LUM RAMABAJA Bachelor’s Student in Bioinformatics ‘Bioinformatics is a truly interesting field. The program has inspired me to apply what I have learned and help people by starting a company that diagnoses malaria.’ To The Point KRISTINA PREUER BSc MSc Graduate in Bioinformatics
Bioinformatics, Stellenbosch University Many bioinformatics tools and resources are available on the command-line interface These are often on the Linux platform (or other Unix-like platforms such as the Mac command line). They are essential for many bioinformatics and genomics applications.
Bioinformatics is an interdisciplinary area of the science composed of biology, mathematics and computer science. Bioinformatics is the application of information technology to manage biological data that helps in decoding plant genomes. The field of bioinformatics emerged as a tool to facilitate biological discoveries more than 10 years ago.
Bioinformatics Bioinformatics is the combination of biology and information technology. The discipline encompasses any computational tools and methods used to manage, analyze and manipulate large sets of biological data. Essentially, bioinformatics has three components: The creation of databases allowing the storage and
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