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Big Secrets in Small The Brain Inflammation Cancer and
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FROM THE DEPUTY DIRECTOR FOR INTRAMURAL RESEARCH, Taking Stock of the NIH Research Festival. Don t Miss the Very Best that NIH Has to Offer, BY MICHAEL GOTTESMAN DDIR. The 2017 NIH Intramural Research and workshops reflecting the interests of why don t more of us attend our Research. Festival co chaired by scientific directors our scientific interest groups Every year Festival In a survey we conducted several. Susan Amara NIMH and Steve Cha two different scientific directors with years ago we found that the major reason. nock NCI s Division of Cancer Epidemi complementary interests are asked to given by our fellows for not attending NIH. ology and Genetics was by most accounts manage the festival Plenary session themes lectures and scientific events such as the. an amazing scientific potpourri of inno this year included the BRAIN Initiative Research Festival and the NIH Director s. vative research and new biotechnology as inflammatory diseases and the Cancer Wednesday Afternoon Lecture Series was. well as an opportunity to showcase the Moonshot conflicting activities the research itself. work of our trainees and fellows in the Other popular events included the deadlines involving publication and other. context of the long term goals administrative requirements. for intramural research and other events of which, Yet attendance was at best there are many at the NIH. modest for most of the sessions If research conferences are an So in setting priorities NIH. What should we do to encourage communal research activities. all of our scientif ic staff to, essential element of our discipline most of which are not spot on. participate more fully more of us should attend our focused on the lab or clinical. Let s take a step back to work of the scientist get less. review the purpose and history of, Research Festival attention Why is not giving.
the festival It had its beginnings the Research Festival a higher. in 1986 when then Scientific Director Technical Sales Association tent show priority a strategic mistake Most of the. Abner Notkins NIDCR dreamed up the of scientific equipment and services and truly paradigm shifting science in modern. idea for the first NIH Intramural Research poster sessions featuring posters from our biology has come from interactions among. Day His goal was to bring our scientific postdoctoral fellows NIH leadership and people in multiple different fields Given the. staff out of their laboratories and clinics future leaders who are being recruited for rich intellectual environment at the NIH. to meet each other in an informal setting positions at the NIH And there was more with over 1 000 principal investigators. to share research and receive constructive special exhibits on resources for intramural and nearly 3 000 postdoctoral fellows we. feedback and to enhance opportunities research a Green Labs Fair featuring the are in a prime position to generate truly. for collaboration There were anecdotes latest in green tools and techniques exciting collaborations just within the. then that NIH intramural scientists were virtual reality demonstrations and an NIH This is precisely the same reason. meeting for the first time at national animal tribute ceremony acknowledging for the Wednesday Afternoon Lectures. and international scientific meetings So the important role animals play in research which are designed to stimulate trans. Research Day was intended as a way to Since a festival should be festive we disciplinary approaches across the more. get NIH scientists to meet each other on had food provided by local vendors and thematic lines of institutes and centers ICs. campus refreshments at the workshops and poster We have tried to encourage collaborations. The Research Festival has evolved into sessions One year we even had a battle of in many ways including providing funding. a multiday event We have added a mix the bands featuring NIH directors for trans NIH collaborations through the. of plenary sessions focusing on themes For scientists who argue convincingly new Innovation Awards program through. developed by the scientific directors who and consistently that research conferences the established Bench to Bedside program. lead each year s festival program committee are an essential element of their discipline through IC based grants for this purpose. 2 THE NIH CATALYST NOVEMBER DECEMBER 2017, NEWS BRIEFS. NIH Partners with 11, Biopharmaceutical, On Thursday October 12 2017 the. NIH and 11 leading biopharmaceutica l, companies launched the Partnership for. and via shared resources and shared core Accelerating Cancer Therapies PACT. facilities https nih scientist com Our a f ive yea r publ ic private resea rch. Norman E Ned Sharpless is the new director of NCI, newly renovated IRP website https irp collaboration totaling 215 million as. nih gov communicates the excitement and part of the Cancer Moonshot PACT will. the diversity of NIH science and the NIH Norman Sharpless initially focus on identifying developing. Intramural Database https intramural, nih gov allows anyone to find a colleague.
Sworn in as New NCI and validating robust biomarkers to. advance new immunotherapy treatments, with a resource or interest that would lead Director for cancer The partnership will be. to fruitful collaboration managed by the Foundation for the. But nothing replaces the one on one Norman E Ned S h arpless took National Institutes of Health with the. interactions and conversations that occur the oath of office on October 17 2017 to Food and Drug Administration serving. at the Research Festival and the chance become the 15th director of the National in an advisory role. for anyone who attends to be guided Cancer Institute NCI He succeeded New immunotherapies have resulted. through what is most exciting currently in Harold E Varmus who stepped down in dramatic responses in certain cancer. NIH intramural research even if it does as director in March 2015 Douglas R cases They have also been the focus of. not coincide with their current research Lowy was NCI s acting director since intense investment by biopharmaceutical. program April 2015 companies seeking to provide new options. We have set the dates for next year s Sharpless comes to NCI from the for patients who do not respond to other. Research Festival September 12 14 University of North Carolina School of cancer therapies but they don t work for all. 2018 and want to encourage all of you Medicine Chapel Hill North Carolina patients Development and standardization. to participate more fully We will remind where he served as director of the NCI of biomarkers to understand how. you through the year about the event in Designated Lineberger Comprehensive immunotherapies work in some patients. hopes that you will not schedule other Cancer Center and as the Wellcome and to predict their response to treatment. activities during this time I will continue Distinguished Professor in Cancer are urgently needed. to remind you in forums such as this how Research As a practicing oncologist at the PACT will facilitate information sharing. important it is for career development and North Carolina Cancer Hospital Chapel by all stakeholders to better coordinate clinical. enhancement to think outside the box And Hill the clinical arm of Lineberger he efforts align investigative approaches reduce. we will ensure that the NIH Research specialized in the care of patients with duplication and enable more high quality. Festival continues to highlight our best hematologic cancers He is the author of trials to be conducted. and most exciting science more than 150 original scientific papers. If you tend to pass on such events you reviews and book chapters and is an For more information about PACT visit. may be missing the very best of what NIH inventor on 10 patents His research has bit ly 2gqGCyu. has to offer a chance to learn new things focused on the molecular biology of cancer. from experts within our midst We craft and aging, the Research Festival to highlight scientific Lowy will resume his role as a deputy. trends and to provide you with insight into director at NCI and will continue his work as Read more online at https irp nih gov. where the IRP is heading and who is doing chief of the Laboratory of Cellular Oncology catalyst v25i6 news briefs. what in NCI s Center for Cancer Research, As always I welcome your ideas. https irp nih gov catalyst 3, Gisela Storz, CONTINUED FROM PAGE 1. years of studying sRNAs primarily in E coli Storz also explained how she is. the Storz lab has shown that sRNAs are part developing more systematic approaches to. of many response pathways in bacterial cells find small proteins One of her postdocs. More recent work in the lab has indicated Jeremy Weaver is working on a mass. that small proteins also play an important spectrometry approach for identifying small. regulatory function proteins in bacterial cells, The sRNAs and proteins are often not At the end of her lecture Storz men.
detected by genetic screens or biochemical tioned the pioneering women who were. assays Storz noted that many of the sRNAs her mentors the late biochemists Thressa. and small proteins that laid the foundation Stadtman National Heart Lung and. for this field were discovered by serendipity Blood Institute and Claude Klee NCI. It has since been recognized that sRNAs and her ongoing collaborator microbiologist. regulate bacterial adaptation to various Susan Gottesman NCI Stadtman was. environmental conditions including cell known for her work on anaerobic electron. BILL BRANSON, envelope stress iron availability and carbon transport and selenium biochemistry Klee. metabolism Adaptation to these environ is remembered for her pioneering work on. ments is often essential for bacterial survival the biochemistry of calcium dependent sig. and virulence Regulatory sRNAs can func Gisela Storz a distinguished investigator at the National naling and calcium binding proteins And. Institute of Child Health and Human Development and a. tion in primarily two ways 1 as protein Gottesman is well known for her work in. member of the National Academy of Sciences does research. binding sRNAs that titrate the activity of on the identification and characterization of small noncoding the area of regulated proteolysis and the. proteins and 2 as antisense sRNAs the RNAs and of small proteins made up of 50 amino acids or less co discovery and characterization of many. more common type that bind to a target bacterial sRNAs. messenger RNA mRNA thereby affect identified four sRNAs and showed that the Their support was subtle Storz said. ing transcription stability or translation of overexpression of one of them results in cells but their assistance with some early experi. the mRNA In her lecture Storz focused with significantly more flagella ments and invitations to give seminars had. on the latter class of regulatory sRNAs While studying sRNAs the Storz lab a positive impact They also served as role. She described how her lab with the help kept stumbling across small proteins and models for achieving balance between. of then postdoc Taylor Updegrove now in started to characterize their function For career and family life Storz noted that. the National Cancer Institute NCI col example a former postdoc in the Storz lab these role models all had spouses at NIH. laborated with researchers at the University Lauren Waters now at the University of and how the recruitment of two career. of California at San Francisco to show that Wisconsin Oshkosh showed that a short couples at the NIH provides a unique. an sRNA called MicL was regulating the open reading frame in the sRNA RybA mechanism for improving the retention. outer membrane lipoprotein lipoma pre encoded a small protein It is currently of women in science. ferred partner the most abundant protein hypothesized that the small protein regu. in E coli Genes Dev 28 1620 1634 2014 lates the activity of the manganese exporter To watch a videocast of Storz s Anita Roberts. Most of the sRNA mRNA systems The small protein that has been most lecture The Hidden Secrets of Small Genes. studied to date were discovered at the level characterized by the Storz lab is AcrZ held on May 16 2017 go to https videocast. of each individual sRNA but the Storz which co purifies with a component of a nih gov launch asp 23286. lab and others have moved to more global multidrug efflux pump that confers resis. genomic approaches for identifying sRNAs tance to a variety of antibiotics and other. and their mRNA targets Sahar Melamed compounds in E coli Interestingly cells. Read more online at https irp nih, a postdoctoral fellow in the Storz lab is lacking AcrZ are only sensitive to a subset. gov catalyst v25i6 gisela storz phd, using a deep sequencing approach termed of these drugs suggesting that AcrZ affects. discovering big secrets in small genes, RIL seq that he developed at the Hebrew the specificity of drug export Proc Natl Acad. University of Jerusalem Jerusalem He has Sci U S A 109 16696 16701 2012. 4 THE NIH CATALYST NOVEMBER DECEMBER 2017, Insights from Former Surgeon General Vivek Murthy.
Rising Stress Causes and Remedies, BY SUSAN CHACKO CIT. children to drink lead tainted water He met of violence The students were skeptical at. students and discovered that 95 percent of first but as they practiced meditation over a. them had suffered unbearable stress in the year the school became noticeably calmer. previous month Everywhere he saw people and had a drastically reduced suspension. of the Escherichia coli transcription factor OxyR is regulated by a reversible disulfide bond formation Science 279 1718 1721 1998 Her group also serendipitously found one of the first small regulatory RNAs the OxyS RNA Cell 90 43 53 1997 Today her lab focuses on the identification and characterization of small noncoding RNAs

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